4-tert-butyl-N-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)benzamide

Base Information

Chemical Name:4-tert-butyl-N-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)benzamide
CAS No.:1147528-82-2
Molecular Formula:C₃₃H₃₆N₆O₄
Molecular Weight:580.687
Hs Code.:

Synonyms:4-tert-butyl-N-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)benzamide

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Chemical Property of 4-tert-butyl-N-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)benzamide

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Technology Process of 4-tert-butyl-N-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)benzamide

There total 6 articles about 4-tert-butyl-N-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 910235-65-3
4-tert-butyl-N-[2-methyl-3-(4,4,5,5-tetramethyl-[1,2,3]dioxaborolan-2-yl)-phenyl]-benzamide

: 1147530-59-3
6-chloro-2-methyl-4-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)-2,3-dihydropyridazin-3-one

: 1147528-82-2
4-tert-butyl-N-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)benzamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 175 ℃; for 0.5h; Microwave irradiation;

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 1147528-82-2
4-tert-butyl-N-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 5 h / Inert atmosphere; Reflux

2: hydrogen; palladium on activated charcoal / ethanol / 6 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 40 h / 20 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.25 h / 170 °C / Inert atmosphere; Microwave irradiation

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; potassium acetate; sodium carbonate; triethylamine; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 4: |Suzuki Coupling;
DOI:10.1021/jm500305p

Reference yield:

: 910235-64-2
2-(2-methyl-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1147528-82-2
4-tert-butyl-N-(2-methyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)pyridin-2-ylamino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium on activated charcoal / ethanol / 6 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 40 h / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 0.25 h / 170 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 3: |Suzuki Coupling;
DOI:10.1021/jm500305p