910235-65-3Relevant articles and documents
Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors
Qiu, Hui,Ali, Zahid,Bender, Andrew,Caldwell, Richard,Chen, Yi-Ying,Fang, Zhizhou,Gardberg, Anna,Glaser, Nina,Goettsche, Anja,Goutopoulos, Andreas,Grenningloh, Roland,Hanschke, Bettina,Head, Jared,Johnson, Theresa,Jones, Christopher,Jones, Reinaldo,Kulkarni, Shashank,Maurer, Christine,Morandi, Federica,Neagu, Constantin,Poetzsch, Sven,Potnick, Justin,Schmidt, Ralf,Roe, Katherine,Viacava Follis, Ariele,Wing, Carolyn,Zhu, Xiaohua,Sherer, Brian
, (2021)
Bruton's tyrosine kinase (BTK) is a cytoplasmic, non-receptor tyrosine kinase member of the TEC family of tyrosine kinases. Pre-clinical and clinical data have shown that targeting BTK can be used for the treatment for B-cell disorders. Here we disclose t
Pyrrolopyrimidine BTK inhibitor as well as preparation method and application thereof
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, (2021/11/03)
The invention provides a pyrrolopyrimidine BTK inhibitor as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The compound has the structural general formula shown in a formula (I). In-flight
NOVEL IRREVERSIBLE BRUTON'S TYROSINE KINASE INHIBITOR
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, (2019/01/04)
The present invention provides an inhibitor of Bruton's tyrosine kinase, which is a compound of formula (I), or its pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug. The present invention also provides a pharmaceutical composition comprsing the compound. The present invention also provides a method for inhibiting the activity of tyrosine kinase activity or for treating a disease, disorder, or condition, which would benefit from the inhibition of Bruton's tyrosine kinase(s), by using the Bruton's tyrosine kinase inhibitor, as well as application of the Bruton's tyrosine kinase inhibitor for the same.