{2-[((S)-1-Carbamoyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {2-[((S)-1-Carbamoyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester
• CAS No.: 157974-11-3
• Molecular Formula: C₁₉H₂₉N₃O₄
• Molecular Weight: 363.457
• Mol file: 157974-11-3.mol

Synonyms:{2-[((S)-1-Carbamoyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester

Chemical Property of {2-[((S)-1-Carbamoyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[((S)-1-Carbamoyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester

There total 2 articles about {2-[((S)-1-Carbamoyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(S)-(+)-α-methylamino-β-phenylpropionamide (17193-30-5) + N-t-butoxycarbonyl-N-methyl-β-alanine (124072-61-3) → {2-[((S)-1-Carbamoyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester (157974-11-3)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00037a005

Reference yield:

3-(tert-butyloxycarbonylamino)propionic acid (3303-84-2) → {2-[((S)-1-Carbamoyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester (157974-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 16 h

2: 74 percent / NMM, N-hydroxybenzotriazole hydrate, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

With 4-methyl-morpholine; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00037a005

Reference yield: 100.0%

{2-[((S)-1-Carbamoyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester (157974-11-3) → (S)-2-[Methyl-(3-methylamino-propionyl)-amino]-3-phenyl-propionamide; compound with trifluoro-acetic acid

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/jm00037a005

upstream raw materials:

(S)-(+)-α-methylamino-β-phenylpropionamide

N-t-butoxycarbonyl-N-methyl-β-alanine

3-(tert-butyloxycarbonylamino)propionic acid