17193-30-5

Basic information

• Product Name: hydrocinnamamide
• Synonyms: hydrocinnamamide
• CAS NO: 17193-30-5
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 149.18974
• Mol File: 17193-30-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 353.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.078±0.06 g/cm3(Predicted)
• PKA: 15.99±0.50(Predicted)
• CAS DataBase Reference: hydrocinnamamide(CAS DataBase Reference)
• NIST Chemistry Reference: hydrocinnamamide(17193-30-5)
• EPA Substance Registry System: hydrocinnamamide(17193-30-5)

Safety Data

• Hazardous Substances Data: 17193-30-5(Hazardous Substances Data)

Upstream product

• 77128-73-5 (2S)-N-fluorenylmethyloxycarbonyl-2-amino-N-methyl-3-phenylpropanoic acid 
• 2899-07-2 (S)-N-benzyloxycarbonyl-N-methyl-phenyl alanine 
• 2812-24-0 (S)-ethyl-2-(methylamino)-3-phenylpropanoate 
• 2566-30-5 N-Methyl-L-phenylalanine 

Downstream Products

• 111540-45-5 Boc-Asp(OBzl)-(NMe)Phe-NH₂ 
• 157974-05-5 Boc-Gly-N-MePhe-NH₂ 
• 2566-30-5 N-Methyl-L-phenylalanine 
• 56564-52-4 N-methyl-D-phenylalanine 
• 134675-58-4 Boc-Trp-3PP-Asp(OBn)-(N-Me)Phe-NH₂ 
• 134676-16-7 (S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-N-methyl-3-[((2S,3S)-3-propyl-pyrrolidine-2-carbonyl)-amino]-succinamic acid benzyl ester; hydrochloride 
• 131450-72-1 H-Asp(OBn)-N(Me)Phe-NH₂ hydrochloride salt 
• 134676-15-6 Boc-3PP-Asp(OBn)-(N-Me)Phe-NH₂ 

Relevant articles and documents

Chemical models of peptide formation in translation

Ribosomal incorporations of N-alkyl amino acids including proline are slower than incorporations of non-N-alkyl L-amino acids. The chemical reactivity hypothesis proposes that these results and the exclusion of nonproline N-alkyl amino acids from the gene

Development of Potent and Selective CCK-A Receptor Agonists from Boc-CCK-4: Tetrapeptides Containing Lys(Nε)-Amide Residues

A series of Boc-CCK-4 derivatives represented by the general structure Boc-Trp-Lys(Nε-COR)-Asp-Phe-NH2, where R is an aromatic, heterocyclic, or aliphatic group, are potent and selective CCK-A receptor agonists.These amide-bearing compounds complement the previously described urea-based tetrapeptides (Shiosaki et al.J.Med.Chem. 1991,34,2837-2842); structure-activity studies revealed parallel as well as divergent trends between these two series.A significant correlation was observed between pancreatic binding affinity and the resonance constant R of the phenyl substituent in one particular series of derivatives.Sulfation of phenolic amides appended onto the ε-amino group of the lysine did not affect affinity for the CCK-A receptor in contrast to the 500-fold increase in binding potency observed upon sulfation of CCK-8, suggesting that the lysine appendage and the sulfated tyrosine in CCK-8, both key structural elements that impart high affinity for the CCK-A receptor, are interacting differently with the receptor.The amide-bearing tetrapeptides are full agonists relative to CCK-8 in stimulating pancreatic amylase release while being partial agonists in eliciting phosphoinositide (PI) hydrolysis.Both effects were blocked by selective CCK-A receptor antagonists

Polypeptides. VII. Variations of the phenylalanyl position in the C-terminal tetrapeptide amide sequence of the gastrins.

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