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124072-61-3

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124072-61-3 Usage

General Description

3-(Methylamino)propanoic acid, N-BOC protected is a chemical compound that is a derivative of propanoic acid with a methylamino group attached to the third carbon of the carbon chain. The compound is N-BOC protected, which means that the amino group is protected with a tert-butoxycarbonyl (BOC) group to prevent undesired reactions or interactions. 3-(Methylamino)propanoic acid, N-BOC protected has potential applications in organic synthesis and pharmaceutical research, where the N-BOC protection can be removed under specific conditions to reveal the active amino group for further chemical reactions. 3-(Methylamino)propanoic acid, N-BOC protected may be used as a building block for the synthesis of various organic molecules and pharmaceutical compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 124072-61-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,0,7 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 124072-61:
(8*1)+(7*2)+(6*4)+(5*0)+(4*7)+(3*2)+(2*6)+(1*1)=93
93 % 10 = 3
So 124072-61-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H17NO4/c1-9(2,3)14-8(13)10(4)6-5-7(11)12/h5-6H2,1-4H3,(H,11,12)

124072-61-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]propanoic acid

1.2 Other means of identification

Product number -
Other names 1,4-Piperazinedicarboxylic acid,1,1-dimethylethyl phenylmethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:124072-61-3 SDS

124072-61-3Relevant articles and documents

In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement

Blackwell, Danielle J.,Church, W. David,Desai, Hetvi J.,Keilhack, Heike,Kuntz, Kevin W.,Lu, Alvin Z.,Majer, Christina R.,Niepel, Mario,Perl, Nicholas R.,Ren, Yue,Santospago, Andrew G.,Schenkel, Laurie B.,Swinger, Kerren K.,Vasbinder, Melissa M.,Wigle, Tim J.

, p. 877 - 887 (2020)

Poly(ADP-ribose) polymerase (PARP) enzymes use nicotinamide adenine dinucleotide (NAD+) to modify up to seven different amino acids with a single mono(ADP-ribose) unit (MARylation deposited by PARP monoenzymes) or branched poly(ADP-ribose) polymers (PARylation deposited by PARP polyenzymes). To enable the development of tool compounds for PARP monoenzymes and polyenzymes, we have developed active site probes for use in in vitro and cellular biophysical assays to characterize active site-directed inhibitors that compete for NAD+ binding. These assays are agnostic of the protein substrate for each PARP, overcoming a general lack of knowledge around the substrates for these enzymes. The in vitro assays use less enzyme than previously described activity assays, enabling discrimination of inhibitor potencies in the single-digit nanomolar range, and the cell-based assays can differentiate compounds with sub-nanomolar potencies and measure inhibitor residence time in live cells. Wigle et al. describe a versatile set of NAD+-competitive probes for PARP enzymes that are used to build high-throughput in vitro and cellular biophysical assays that enable inhibitor screening and determination of residence time.

HETEROARYL COMPOUNDS

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Paragraph 00236, (2021/05/29)

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES

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Page/Page column 157, (2014/03/25)

The invention relates to pyrrole carboxamides bearing a fluoromethyl- moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

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