{(S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1,5-dimethyl-cyclohexa-2,5-dienyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone

Base Information

• Chemical Name: {(S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1,5-dimethyl-cyclohexa-2,5-dienyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone
• CAS No.: 145105-11-9
• Molecular Formula: C₂₃H₄₁NO₃Si
• Molecular Weight: 407.669

Synonyms:{(S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1,5-dimethyl-cyclohexa-2,5-dienyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone

Chemical Property of {(S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1,5-dimethyl-cyclohexa-2,5-dienyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {(S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1,5-dimethyl-cyclohexa-2,5-dienyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone

There total 2 articles about {(S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1,5-dimethyl-cyclohexa-2,5-dienyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → {(S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1,5-dimethyl-cyclohexa-2,5-dienyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone (145105-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) lithium amide formation

2: 1.) K, NH₃ / 1.) THF, t-BuOH

With ammonia;

DOI:10.1016/S0040-4039(00)60998-X

Reference yield:

{2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-phenyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone (145105-09-5) + methyl iodide (74-88-4) → {(S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1,5-dimethyl-cyclohexa-2,5-dienyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone (145105-11-9)

Guidance literature:

With ammonia; Yield given. Multistep reaction; 1.) THF, t-BuOH;

DOI:10.1016/S0040-4039(00)60998-X

Reference yield: 98.0%

{(S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1,5-dimethyl-cyclohexa-2,5-dienyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone (145105-11-9) → (S)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2,4-dimethyl-cyclohexa-2,5-dienone (145105-13-1)

Guidance literature:

With tert.-butylhydroperoxide; dipyridinium dichromate; Celite; In benzene;

DOI:10.1016/S0040-4039(00)60998-X

upstream raw materials:

{2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-methyl-phenyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone

methyl iodide

tert-butyldimethylsilyl chloride

Downstream raw materials:

(S)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2,4-dimethyl-cyclohexa-2,5-dienone

(2S,4S,5R)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2,4-dimethyl-cyclohexanone

(2R,4S,5R)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2,4-dimethyl-cyclohexanone

(2S,4S,5S)-5-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-2,4-dimethyl-cyclohexanone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 145105-11-9 {(S)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1,5-dimethyl-cyclohexa-2,5-dienyl}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone

Send

Send

Metric Ton KG G Pound L ML

Send

Send