hexaazido-hepta-O-acetyl neomycin

Base Information

• Chemical Name: hexaazido-hepta-O-acetyl neomycin
• CAS No.: 474266-81-4
• Molecular Formula: C₃₇H₄₈N₁₈O₂₀
• Molecular Weight: 1064.9
• Mol file: 474266-81-4.mol

Synonyms:hexaazido-hepta-O-acetyl neomycin

Chemical Property of hexaazido-hepta-O-acetyl neomycin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hexaazido-hepta-O-acetyl neomycin

There total 2 articles about hexaazido-hepta-O-acetyl neomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

neomycin B (119-04-0) + acetic anhydride (108-24-7) → hexaazido-hepta-O-acetyl neomycin (474266-81-4)

Guidance literature:

neomycin B; With triflic azide; copper(II) sulfate; triethylamine; In methanol; water;

acetic anhydride; With pyridine; dmap; Further stages.;

DOI:10.1021/ol026548n

Reference yield:

neomycin B (119-04-0) → hexaazido-hepta-O-acetyl neomycin (474266-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(II) sulfate; triflic azide / dichloromethane; water

2: dmap; pyridine / 20 °C

With pyridine; dmap; triflic azide; copper(II) sulfate; In dichloromethane; water;

DOI:10.3390/molecules24030580

Reference yield: 90.0%

para-thiocresol (106-45-6) + hexaazido-hepta-O-acetyl neomycin (474266-81-4) → 1,3,2′,6′-tetraazido-6,3′,4′-tri-O-acetylneamine (182554-04-7) + acetic acid 4-acetoxy-6-(4-acetoxy-2-acetoxymethyl-5-p-tolylsulfanyl-tetrahydrofuran-3-yloxy)-5-azido-2-azidomethyl-tetrahydro-pyran-3-yl ester (474266-82-5)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 25 ℃; for 15h;

DOI:10.1021/ol026548n

upstream raw materials:

neomycin B

acetic anhydride

Downstream raw materials:

5,6,3',4'-tetra-O-acetyl-1,3,2',6'-tetrazidoneamine

acetic acid 4-acetoxy-6-(4-acetoxy-2-acetoxymethyl-5-p-tolylsulfanyl-tetrahydrofuran-3-yloxy)-5-azido-2-azidomethyl-tetrahydro-pyran-3-yl ester

hexaazido-hepta-O-benzyl neomycin

1,3,2′,6′-tetraazido-6,3′,4′-tri-O-acetylneamine