N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-2H-pyrano[3,2-b]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Base Information

• Chemical Name: N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-2H-pyrano[3,2-b]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine
• CAS No.: 1438073-62-1
• Molecular Formula: C₂₆H₃₀ClFN₄O₃
• Molecular Weight: 501.001
• Mol file: 1438073-62-1.mol

Synonyms:N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-2H-pyrano[3,2-b]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Chemical Property of N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-2H-pyrano[3,2-b]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-2H-pyrano[3,2-b]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine

There total 15 articles about N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-2H-pyrano[3,2-b]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

5-(3-chloropropyl)octahydro-2H-pyrano[3,2-b]pyridine (1438083-77-2) + 4-(3-chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline (184475-71-6) → N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-2H-pyrano[3,2-b]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine (1438073-62-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 7h;

Reference yield:

6-acetoxy-4-chloro-7-methoxyquinazoline (230955-75-6) → N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-2H-pyrano[3,2-b]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine (1438073-62-1)

Guidance literature:

Multi-step reaction with 3 steps

1: isopropyl alcohol / 5 h / 88 °C

2: water; sodium hydroxide / methanol / 6 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 7 h / 80 °C

With water; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one (179688-53-0) → N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-2H-pyrano[3,2-b]pyridin-5(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine (1438073-62-1)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / N,N-dimethyl-formamide / 3 h / 70 °C

2: isopropyl alcohol / 5 h / 88 °C

3: water; sodium hydroxide / methanol / 6 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 7 h / 80 °C

With thionyl chloride; water; potassium carbonate; sodium hydroxide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one

6-acetoxy-4-chloro-7-methoxyquinazoline

4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

5-(3-chloropropyl)octahydro-2H-pyrano[3,2-b]pyridine