4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate

Base Information

Chemical Name:4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
CAS No.:788136-89-0
Molecular Formula:C17H13ClFN3O3
Molecular Weight:361.76
Hs Code.:2933990090
Mol file:788136-89-0.mol

Synonyms:6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-, acetate (ester) (9CI);6-Acetoxy-4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazoline;4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol 6-acetate;

Suppliers and Price of 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate 95+%
250mg
$ 521.00

Matrix Scientific
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate 95+%
1g
$ 1143.00

Crysdot
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ylacetate 95+%
25g
$ 287.00

Chemenu
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ylacetate 95%
25g
$ 271.00

Chemenu
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ylacetate 95%
10g
$ 148.00

AvaChem
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
10g
$ 850.00

AvaChem
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
100mg
$ 85.00

AvaChem
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
1g
$ 285.00

Arctom
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ylacetate 95%
25g
$ 123.00

Arctom
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ylacetate 95%
10g
$ 63.00

Total 81 raw suppliers

Chemical Property of 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate

Chemical Property:

Refractive Index:1.649
Boiling Point:471.5 °C at 760 mmHg
PKA:5.22±0.30(Predicted)
Flash Point:238.9 °C
PSA：73.34000
Density:1.425 g/cm³
LogP:4.17280
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl Acetate, is an impurity of Gefitinib (G304000), an antineoplastic.

Technology Process of 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate

There total 19 articles about 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 948551-62-0
C₁₁H₁₁ClN₂O₃

: 367-22-6
4-chloro-3-fluoroaniline

: 788136-89-0
4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

Guidance literature:: In isopropyl alcohol; at 110 ℃; for 3h;

Reference yield: 99.0%

: 367-21-5
3-chloro-4-fluorophenylamine

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 788136-89-0
4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

Guidance literature:: In isopropyl alcohol; for 2h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2009.11.035

Reference yield: 78.0%

: 179688-53-0
(4-hydroxy-7-methoxyquinazolin-6-yl) acetate

: 367-21-5
3-chloro-4-fluorophenylamine

: 788136-89-0
4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

Guidance literature:: 4-hydroxy-7-methoxyquinazolin-6-yl acetate; With thionyl chloride; In N,N-dimethyl-formamide; for 6h; Reflux;

3-chloro-4-fluorophenylamine; With triethylamine; In N,N-dimethyl-formamide; isopropyl alcohol; at 20 ℃; for 9h; Reflux;
DOI:10.1016/j.ejmech.2016.12.055