4-Methoxy-2,6-dimethylaniline

Base Information

• Chemical Name: 4-Methoxy-2,6-dimethylaniline
• CAS No.: 34743-49-2
• Molecular Formula: C9H13 N O
• Molecular Weight: 151.208
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID00956230
• Nikkaji Number: J3.600.066J
• Wikidata: Q82936210
• Mol file: 34743-49-2.mol

Synonyms:4-methoxy-2,6-dimethylaniline;34743-49-2;Benzenamine, 4-methoxy-2,6-dimethyl-;4-METHOXY-2,6-DIMETHYL-ANILINE;2,6-dimethyl-4-methoxyaniline;4-Methoxy-2,6-dimethylbenzenamine;MFCD03792670;2,6-dimethyl-4-methoxy-aniline;SCHEMBL3439540;DTXSID00956230;AMY19070;4-Methoxy-2,6-dimethyl-phenylamine;BBL034370;CL9312;STL383204;AKOS016003684;CS-W005568;SB76297;DS-16737;SY111604;FT-0744798;J3.600.066J

Chemical Property of 4-Methoxy-2,6-dimethylaniline

Chemical Property:

• Vapor Pressure: 0.00779mmHg at 25°C
• Melting Point: 36-37 °C
• Boiling Point: 268.2°Cat760mmHg
• PKA: 4.91±0.10(Predicted)
• Flash Point: 122°C
• PSA: 35.25000
• Density: 1.019g/cm³
• LogP: 2.47540
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 115

Purity/Quality:

98% ^*data from raw suppliers

4-Methoxy-2,6-dimethylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1N)C)OC

Technology Process of 4-Methoxy-2,6-dimethylaniline

There total 17 articles about 4-Methoxy-2,6-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chloro-3,5-dimethylanisole (6981-15-3) → 4-methoxy-2,6-dimethylaniline (34743-49-2)

Guidance literature:

With C₂₈H₃₀Cl₅N₃Pd; ammonia; lithium isopropoxide; sodium t-butanolate; In 1,4-dioxane; at 100 ℃; for 2h; Reagent/catalyst; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.organomet.6b00830

Reference yield: 78.0%

5-methoxy-1,3-dimethyl-2-nitrobenzene (61019-03-2) → 4-methoxy-2,6-dimethylaniline (34743-49-2)

Guidance literature:

5-methoxy-1,3-dimethyl-2-nitrobenzene; With tin(ll) chloride; In ethanol; Heating / reflux;

With sodium hydroxide; water;

Reference yield: 77.0%

tert-butyl (4-methoxy-2,6-dimethylphenyl)carbamate → 4-methoxy-2,6-dimethylaniline (34743-49-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

methanol

N-(2,6-dimethylphenyl)hydroxylamine

5-methoxy-1,3-dimethyl-2-nitrobenzene

1-(4-methoxy-2,6-dimethylphenyl)-2-phenyldiazene

Downstream raw materials:

benzenesulfonic acid-(4-methoxy-2,6-dimethyl-anilide)

C₂₂H₂₂ClN₅O₂

(E,E)-N,N'-(pyridine-2,6-diylbis-(methanylylidene))bis(4-methoxy-2,6-dimethylaniline)

Refernces

• 1、 -. "PYRAZOLOPYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTING OR TREATING CANCER, AUTOIMMUNE DISEASE AND BRAIN DISEASE CONTAINING THE SAME AS AN ACTIVE INGREDIENT". Paragraph 628-632. . Retrieved 2018/12/02.
• 2、 Ruff, Yves,Berst, Frédéric. "Efficient copper-catalyzed amination of DNA-conjugated aryl iodides under mild aqueous conditions". supporting information. p. 1188 - 1193. Retrieved 2018/08/01.