1,1,1,3-tetrahydro-1-(2,4,6-trimethylphenyl)-1-[2,2-bis(4-chlorophenyl)-2-hydroxyethyl]-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole

Base Information

Chemical Name:1,1,1,3-tetrahydro-1-(2,4,6-trimethylphenyl)-1-[2,2-bis(4-chlorophenyl)-2-hydroxyethyl]-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole
CAS No.:445041-27-0
Molecular Formula:C₃₂H₂₇Cl₂F₆O₂P
Molecular Weight:659.435
Hs Code.:

Synonyms:1,1,1,3-tetrahydro-1-(2,4,6-trimethylphenyl)-1-[2,2-bis(4-chlorophenyl)-2-hydroxyethyl]-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole

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Chemical Property of 1,1,1,3-tetrahydro-1-(2,4,6-trimethylphenyl)-1-[2,2-bis(4-chlorophenyl)-2-hydroxyethyl]-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole

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Technology Process of 1,1,1,3-tetrahydro-1-(2,4,6-trimethylphenyl)-1-[2,2-bis(4-chlorophenyl)-2-hydroxyethyl]-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole

There total 3 articles about 1,1,1,3-tetrahydro-1-(2,4,6-trimethylphenyl)-1-[2,2-bis(4-chlorophenyl)-2-hydroxyethyl]-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 445041-26-9
1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide

: 917-54-4
methyllithium

: 90-98-2
4,4'-Dichlorobenzophenone

: 445041-27-0
1,1,1,3-tetrahydro-1-(2,4,6-trimethylphenyl)-1-[2,2-bis(4-chlorophenyl)-2-hydroxyethyl]-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole

Guidance literature:: 1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide; methyllithium; In tetrahydrofuran; at 20 ℃; for 0.5h;

4,4'-Dichlorobenzophenone; In tetrahydrofuran; at 20 ℃; for 4h;

With lithium aluminium tetrahydride; In tetrahydrofuran; Further stages.;
DOI:10.1021/ja0170145

Reference yield:

: 718-64-9
1,1,1,3,3,3-hexafluoro-2-phenylisopropyl alcohol

: 445041-27-0
1,1,1,3-tetrahydro-1-(2,4,6-trimethylphenyl)-1-[2,2-bis(4-chlorophenyl)-2-hydroxyethyl]-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi; TMEDA / tetrahydrofuran / 9 h / 20 °C

1.2: 26 percent / S₈ / tetrahydrofuran / 3 h / Heating

2.1: tetrahydrofuran / 0.5 h / 20 °C

2.2: tetrahydrofuran / 4 h / 20 °C

2.3: 59 percent / LiAlH₄ / tetrahydrofuran

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran;
DOI:10.1021/ja0170145

Reference yield:

: 6781-96-0
dichloro(mesityl)phosphane

: 445041-27-0
1,1,1,3-tetrahydro-1-(2,4,6-trimethylphenyl)-1-[2,2-bis(4-chlorophenyl)-2-hydroxyethyl]-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole

Guidance literature:: Multi-step reaction with 2 steps

1.1: BuLi; TMEDA / tetrahydrofuran / 9 h / 20 °C

1.2: 26 percent / S₈ / tetrahydrofuran / 3 h / Heating

2.1: tetrahydrofuran / 0.5 h / 20 °C

2.2: tetrahydrofuran / 4 h / 20 °C

2.3: 59 percent / LiAlH₄ / tetrahydrofuran

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran;
DOI:10.1021/ja0170145