1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide

Base Information

• Chemical Name: 1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide
• CAS No.: 445041-26-9
• Molecular Formula: C₁₈H₁₅F₆OPS
• Molecular Weight: 424.347
• Mol file: 445041-26-9.mol

Synonyms:1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide

Chemical Property of 1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide

There total 1 articles about 1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

1,1,1,3,3,3-hexafluoro-2-phenylisopropyl alcohol (718-64-9) + dichloro(mesityl)phosphane (6781-96-0) → 1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide (445041-26-9)

Guidance literature:

1,1,1,3,3,3-hexafluoro-2-phenylisopropyl alcohol; dichloro(mesityl)phosphane; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 20 ℃; for 9h;

With sulfur; In tetrahydrofuran; for 3h; Further stages.; Heating;

DOI:10.1021/ja0170145

Reference yield: 59.0%

1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide (445041-26-9) + methyllithium (917-54-4) + 4,4'-Dichlorobenzophenone (90-98-2) → 1,1,1,3-tetrahydro-1-(2,4,6-trimethylphenyl)-1-[2,2-bis(4-chlorophenyl)-2-hydroxyethyl]-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole (445041-27-0)

Guidance literature:

1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide; methyllithium; In tetrahydrofuran; at 20 ℃; for 0.5h;

4,4'-Dichlorobenzophenone; In tetrahydrofuran; at 20 ℃; for 4h;

With lithium aluminium tetrahydride; In tetrahydrofuran; Further stages.;

DOI:10.1021/ja0170145

Reference yield:

1,3-dihydro-3,3-bis(trifluoromethyl)-1-(2,4,6-trimethylphenyl)-3H-2,1-benzoxaphosphole 1-sulfide (445041-26-9) → [TBPY-5-12]-3',3'-bis(4-chlorophenyl)-1-(2,4,6-trimethylphenyl)-3,3-bis(trifluoromethyl)spiro[2,1-benzoxaphosphole-1(3H),2'λ5-[1,2]oxaphosphetane]

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.5 h / 20 °C

1.2: tetrahydrofuran / 4 h / 20 °C

1.3: 59 percent / LiAlH₄ / tetrahydrofuran

2.1: n-BuLi / diethyl ether / 0 °C

2.2: 80 percent / I₂ / diethyl ether / 0 °C

With n-butyllithium; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ja0170145

upstream raw materials:

1,1,1,3,3,3-hexafluoro-2-phenylisopropyl alcohol

dichloro(mesityl)phosphane

Downstream raw materials:

1,1,1,3-tetrahydro-1-(2,4,6-trimethylphenyl)-1-[2,2-bis(4-chlorophenyl)-2-hydroxyethyl]-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole