N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-4-ethylbenzamide

Base Information

Chemical Name:N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-4-ethylbenzamide
CAS No.:1356920-08-5
Molecular Formula:C₃₇H₃₅N₅O₅S
Molecular Weight:661.781
Hs Code.:

Synonyms:N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-4-ethylbenzamide

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Chemical Property of N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-4-ethylbenzamide

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Technology Process of N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-4-ethylbenzamide

There total 4 articles about N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-4-ethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16331-45-6
p-ethylbenzoyl chloride

: 1356920-06-3
3-[(3S,4S)-4-(4-aminophenyl)-3-{[(4S)-4-benzyl-2-oxo1,3-thiazolidin-3-yl]carbonyl}-4-hydroxybutyl]-1,2,3-benzotriazin-4(3H)-one

: 1356920-08-5
N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-4-ethylbenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1356920-08-5
N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-4-ethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium tetrachloride / dichloromethane / 0.33 h / 0 - 25 °C / Inert atmosphere

1.2: 0.33 h / 0 °C / Inert atmosphere

1.3: 2 h / 0 - 25 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 25 °C / 2585.81 Torr / Parr apparatus

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C

With hydrogen; titanium tetrachloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1356920-05-2
3-{(3S)-4-[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]-3-[(S)-hydroxy(4-nitrophenyl)methyl]-4-oxobutyl}-1,2,3-benzotriazin-4(3H)-one

: 1356920-08-5
N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-4-ethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 25 °C / 2585.81 Torr / Parr apparatus

2: triethylamine / dichloromethane / 0.5 h / 0 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;