2-N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalanine

Base Information

Chemical Name:2-N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalanine
CAS No.:1185570-98-2
Molecular Formula:C₂₄H₂₃F₂N₃O₄
Molecular Weight:455.461
Hs Code.:

Synonyms:2-N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalanine

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Chemical Property of 2-N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalanine

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Technology Process of 2-N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalanine

There total 7 articles about 2-N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1185571-70-3
tert-butyl N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalaninate

: 1185570-98-2
2-N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalanine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1185570-76-6
cyclopentyl N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalaninate

: 1185570-98-2
2-N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalanine

Guidance literature:: With water; recombinant hCE-1; at 37 ℃; pH=7.4; Enzyme kinetics; Enzymatic reaction; Aqueous phosphate buffer;

Reference yield:

: 602312-20-9
6-amino-5-(2,4-difluorobenzoyl)-1-[4-(2-hydroxyethyl)phenyl]-pyridin-2(1H)-one

: 1185570-98-2
2-N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalanine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

2.1: tetrahydrofuran / 0.5 h

2.2: 24 h

3.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

With Dess-Martin periodane; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;