tert-butyl N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalaninate

Base Information

Chemical Name:tert-butyl N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalaninate
CAS No.:1185571-70-3
Molecular Formula:C₂₈H₃₁F₂N₃O₄
Molecular Weight:511.569
Hs Code.:

Synonyms:tert-butyl N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalaninate

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Chemical Property of tert-butyl N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalaninate

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Technology Process of tert-butyl N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalaninate

There total 6 articles about tert-butyl N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1151805-31-0
{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetaldehyde

: 4512-32-7
H-Aib-OtBu

: 1185571-70-3
tert-butyl N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalaninate

Guidance literature:: {4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-phenyl}acetaldehyde; H-Aib-OtBu; In tetrahydrofuran; for 0.5h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; for 24h;

Reference yield:

: 4512-31-6
benzyloxycarbonyl-α-aminoisobutyric acid tert-butyl ester

: 1185571-70-3
tert-butyl N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium on activated charcoal / ethyl acetate / 18 h

2.1: tetrahydrofuran / 0.5 h

2.2: 24 h

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 602312-20-9
6-amino-5-(2,4-difluorobenzoyl)-1-[4-(2-hydroxyethyl)phenyl]-pyridin-2(1H)-one

: 1185571-70-3
tert-butyl N-(2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]phenyl}ethyl)-2-methylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

2.1: tetrahydrofuran / 0.5 h

2.2: 24 h

With Dess-Martin periodane; In tetrahydrofuran; dichloromethane;