tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate
• CAS No.: 1052713-78-6
• Molecular Formula: C₁₁H₁₈F₃NO₃
• Molecular Weight: 269.264
• Hs Code.: 2933399990
• Mol file: 1052713-78-6.mol

Synonyms:tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-Hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate

There total 1 articles about tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(trifluoromethyl)trimethylsilane (81290-20-2) + 3-oxo-piperidine-1-carboxylic acid tert-butyl ester (98977-36-7) → tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate (1052713-78-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 19h; Inert atmosphere;

DOI:10.1002/chem.201502084

Reference yield: 99.0%

tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate (1052713-78-6) + benzyl bromide (100-39-0) → N-benzyl-3-hydroxy-3-(trifluoromethyl)piperidine

Guidance literature:

tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

benzyl bromide; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile; at 20 ℃;

DOI:10.1002/chem.201502084

Reference yield: 66.0%

tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate (1052713-78-6) + 1-bromo-2-fluoro-3-methyl-5-nitro-benzene (175610-68-1) → tert-butyl 3-(2-bromo-6-methyl-4-nitrophenoxy)-3-(trifluoromethyl)piperidine-1-carboxylate

Guidance literature:

tert-butyl 3-hydroxy-3-(trifluoromethyl)piperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

1-bromo-2-fluoro-3-methyl-5-nitro-benzene; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

upstream raw materials:

(trifluoromethyl)trimethylsilane

3-oxo-piperidine-1-carboxylic acid tert-butyl ester

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