6,6-difluoro-N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide

Base Information

Chemical Name:6,6-difluoro-N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide
CAS No.:1233929-29-7
Molecular Formula:C₂₀H₂₁F₂N₃O₄S
Molecular Weight:437.467
Hs Code.:

Synonyms:6,6-difluoro-N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide

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Chemical Property of 6,6-difluoro-N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide

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Technology Process of 6,6-difluoro-N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide

There total 6 articles about 6,6-difluoro-N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1233932-23-4
6,6-difluoro-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane

: 103-71-9
phenyl isocyanate

: 1233929-29-7
6,6-difluoro-N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide

Guidance literature:: In tetrahydrofuran; for 0.25h;
DOI:10.1016/j.bmcl.2011.08.094

Reference yield:

: 1067914-81-1
3,3-difluoro-1-(phenylmethyl)-4,4-piperidinediol

: 1233929-29-7
6,6-difluoro-N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 1 h / 150 °C

2: pyridine / 3 h / 20 °C

3: 20% palladium hydroxide on charcoal; hydrogen / tetrahydrofuran; ethanol / 16 h / 20 °C

4: tetrahydrofuran / 0.25 h

With pyridine; 20% palladium hydroxide on charcoal; hydrogen; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; toluene;
DOI:10.1016/j.bmcl.2011.08.094

Reference yield:

: C₁₄H₁₈F₂N₂O

: 1233929-29-7
6,6-difluoro-N-phenyl-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane-8-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 3 h / 20 °C

2: 20% palladium hydroxide on charcoal; hydrogen / tetrahydrofuran; ethanol / 16 h / 20 °C

3: tetrahydrofuran / 0.25 h

With pyridine; 20% palladium hydroxide on charcoal; hydrogen; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2011.08.094