(S)-2-((S)-3-Methylamino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propan-1-ol

Base Information

Chemical Name:(S)-2-((S)-3-Methylamino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propan-1-ol
CAS No.:264271-58-1
Molecular Formula:C₂₈H₄₄N₂O₄
Molecular Weight:472.668
Hs Code.:

Synonyms:(S)-2-((S)-3-Methylamino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propan-1-ol

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Chemical Property of (S)-2-((S)-3-Methylamino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propan-1-ol

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Technology Process of (S)-2-((S)-3-Methylamino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propan-1-ol

There total 5 articles about (S)-2-((S)-3-Methylamino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 264271-71-8
Formic acid (S)-2-((S)-3-formylamino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propyl ester

: 264271-58-1
(S)-2-((S)-3-Methylamino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/ol991401q

Reference yield:

: methyl (αS)-13-hydroxy-α-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-12-oxo-1,6-dioxa-11-azadispiro[4.2.6.2]hexadecane-11-acetate

: 264271-58-1
(S)-2-((S)-3-Methylamino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N; DMAP / CH₂Cl₂ / 6 h / 25 °C

2: 79 percent / NaN₃ / dimethylformamide / 12 h / 25 °C

3: LiAlH₄ / tetrahydrofuran / 2 h / Heating

4: tetrahydrofuran / 0.5 h / 25 °C

5: 207 mg / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With dmap; lithium aluminium tetrahydride; sodium azide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Tosylation / 2: Substitution / 3: Reduction / 4: Formylation / 5: Reduction;
DOI:10.1021/ol991401q

Reference yield:

: 264271-70-7
(S)-2-((S)-3-Amino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propan-1-ol

: 264271-58-1
(S)-2-((S)-3-Methylamino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / 25 °C

2: 207 mg / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; 1: Formylation / 2: Reduction;
DOI:10.1021/ol991401q