(1S,2Z,5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methylene]-dispiro[1,4-diazabicyclo[3.2.1]octan-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Base Information

Chemical Name:(1S,2Z,5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methylene]-dispiro[1,4-diazabicyclo[3.2.1]octan-7,1'-cyclohexane-4',2-[1,3]dioxepane]
CAS No.:264271-62-7
Molecular Formula:C₂₈H₄₀N₂O₃
Molecular Weight:452.637
Hs Code.:

Synonyms:(1S,2Z,5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methylene]-dispiro[1,4-diazabicyclo[3.2.1]octan-7,1'-cyclohexane-4',2-[1,3]dioxepane]

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Chemical Property of (1S,2Z,5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methylene]-dispiro[1,4-diazabicyclo[3.2.1]octan-7,1'-cyclohexane-4',2-[1,3]dioxepane]

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Technology Process of (1S,2Z,5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methylene]-dispiro[1,4-diazabicyclo[3.2.1]octan-7,1'-cyclohexane-4',2-[1,3]dioxepane]

There total 9 articles about (1S,2Z,5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methylene]-dispiro[1,4-diazabicyclo[3.2.1]octan-7,1'-cyclohexane-4',2-[1,3]dioxepane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 264271-61-6
C₂₈H₃₉N₂O₃⁽¹⁺⁾

: 264271-62-7
(1S,2Z,5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methylene]-dispiro[1,4-diazabicyclo[3.2.1]octan-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 25 ℃; for 1h;
DOI:10.1021/ol991401q

Reference yield:

: 2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-3-yl)-N-methyl-acetamide

: 264271-62-7
(1S,2Z,5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methylene]-dispiro[1,4-diazabicyclo[3.2.1]octan-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Guidance literature:: Multi-step reaction with 3 steps

1: 18 mg / K₂CO₃; H₂O / methanol / 2 h / 25 °C

2: DDQ / CH₂Cl₂ / 2 h / 25 °C

3: 11 mg / NaCNBH₃; AcOH / methanol / 1 h / 25 °C

With water; sodium cyanoborohydride; potassium carbonate; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; dichloromethane; 1: Hydrolysis / 2: Oxidation / 3: Reduction;
DOI:10.1021/ol991401q

Reference yield:

: 264271-60-5
(5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-dispiro[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

: 264271-62-7
(1S,2Z,5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methylene]-dispiro[1,4-diazabicyclo[3.2.1]octan-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Guidance literature:: Multi-step reaction with 2 steps

1: DDQ / CH₂Cl₂ / 2 h / 25 °C

2: 11 mg / NaCNBH₃; AcOH / methanol / 1 h / 25 °C

With sodium cyanoborohydride; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; dichloromethane; 1: Oxidation / 2: Reduction;
DOI:10.1021/ol991401q