(5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-dispiro[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Base Information

Chemical Name:(5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-dispiro[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]
CAS No.:264271-60-5
Molecular Formula:C₂₈H₄₀N₂O₃
Molecular Weight:452.637
Hs Code.:

Synonyms:(5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-dispiro[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

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Chemical Property of (5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-dispiro[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

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Technology Process of (5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-dispiro[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

There total 7 articles about (5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-dispiro[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,2,2-trifluoro-N-(1-{1-formyl-2-[4-(3-methyl-but-2-enyloxy)-phenyl]-ethyl}-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-3-yl)-N-methyl-acetamide

: 264271-60-5
(5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-dispiro[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Guidance literature:: With water; potassium carbonate; In methanol; at 25 ℃; for 2h;
DOI:10.1021/ol991401q

Reference yield:

: methyl (αS)-13-hydroxy-α-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-12-oxo-1,6-dioxa-11-azadispiro[4.2.6.2]hexadecane-11-acetate

: 264271-60-5
(5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-dispiro[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N; DMAP / CH₂Cl₂ / 6 h / 25 °C

2: 79 percent / NaN₃ / dimethylformamide / 12 h / 25 °C

3: LiAlH₄ / tetrahydrofuran / 2 h / Heating

4: tetrahydrofuran / 0.5 h / 25 °C

5: 207 mg / LiAlH₄ / tetrahydrofuran / 2 h / Heating

6: Et₃N; DMSO / CH₂Cl₂ / -78 - 0 °C

7: 18 mg / K₂CO₃; H₂O / methanol / 2 h / 25 °C

With dmap; lithium aluminium tetrahydride; sodium azide; water; potassium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Tosylation / 2: Substitution / 3: Reduction / 4: Formylation / 5: Reduction / 6: Oxidation / 7: Hydrolysis;
DOI:10.1021/ol991401q

Reference yield:

: 264271-58-1
(S)-2-((S)-3-Methylamino-9,14-dioxa-1-aza-dispiro[4.2.6.2]hexadec-1-yl)-3-[4-(3-methyl-but-2-enyloxy)-phenyl]-propan-1-ol

: 264271-60-5
(5S)-4-methyl-2-[[4-[(3-methyl-2-butenyl)oxy]phenyl]methyl]-dispiro[1,4-diazabicyclo[3.2.1]oct[2]en-7,1'-cyclohexane-4',2-[1,3]dioxepane]

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N; DMSO / CH₂Cl₂ / -78 - 0 °C

2: 18 mg / K₂CO₃; H₂O / methanol / 2 h / 25 °C

With water; potassium carbonate; dimethyl sulfoxide; triethylamine; In methanol; dichloromethane; 1: Oxidation / 2: Hydrolysis;
DOI:10.1021/ol991401q