D-5,6-O-(1-methylethylidene)-1,4-bis-O-(phenylmethyl)-myo-inositol

Base Information

• Chemical Name: D-5,6-O-(1-methylethylidene)-1,4-bis-O-(phenylmethyl)-myo-inositol
• CAS No.: 438035-28-0
• Molecular Formula: C₂₃H₂₈O₆
• Molecular Weight: 400.472
• Mol file: 438035-28-0.mol

Synonyms:D-5,6-O-(1-methylethylidene)-1,4-bis-O-(phenylmethyl)-myo-inositol

Chemical Property of D-5,6-O-(1-methylethylidene)-1,4-bis-O-(phenylmethyl)-myo-inositol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-5,6-O-(1-methylethylidene)-1,4-bis-O-(phenylmethyl)-myo-inositol

There total 4 articles about D-5,6-O-(1-methylethylidene)-1,4-bis-O-(phenylmethyl)-myo-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-bis(phenylmethoxy)-1,3-benzodioxole (438035-23-5) → D-5,6-O-(1-methylethylidene)-1,4-bis-O-(phenylmethyl)-myo-inositol (438035-28-0,173828-64-3)

Guidance literature:

With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In acetone; at 20 ℃;

DOI:10.1021/jo016237a

Reference yield:

(3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-1,3-benzodioxole-4,7-diol (371155-64-5) → D-5,6-O-(1-methylethylidene)-1,4-bis-O-(phenylmethyl)-myo-inositol (438035-28-0,173828-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH; TBAI / tetrahydrofuran / 0 - 20 °C

2: NMO / OsO₄ / acetone; H₂O / 12 h / 20 °C

With N-methyl-2-indolinone; tetra-(n-butyl)ammonium iodide; sodium hydride; osmium(VIII) oxide; In tetrahydrofuran; water; acetone;

DOI:10.1080/07328300701540225

Reference yield:

benzyl bromide (100-39-0) → D-5,6-O-(1-methylethylidene)-1,4-bis-O-(phenylmethyl)-myo-inositol (438035-28-0,173828-64-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH; TBAI / tetrahydrofuran / 0 - 20 °C

2: NMO / OsO₄ / acetone; H₂O / 12 h / 20 °C

With N-methyl-2-indolinone; tetra-(n-butyl)ammonium iodide; sodium hydride; osmium(VIII) oxide; In tetrahydrofuran; water; acetone;

DOI:10.1080/07328300701540225

upstream raw materials:

(3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-bis(phenylmethoxy)-1,3-benzodioxole

benzyl bromide

(3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-1,3-benzodioxole-4,7-diol

Downstream raw materials:

D-3,4-O-(1-methylethylidene)-2,5-bis-O-(phenylmethyl)-scyllo-inositol 1-monobenzoate

1D-4-O-benzyl-2,3:5,6-di-O-isopropylidene-myo-inositol

myo-inositol 1-phosphate

1L-4-O-benzyl-myo-inositol