(3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-bis(phenylmethoxy)-1,3-benzodioxole

Base Information

• Chemical Name: (3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-bis(phenylmethoxy)-1,3-benzodioxole
• CAS No.: 438035-23-5
• Molecular Formula: C₂₃H₂₆O₄
• Molecular Weight: 366.457
• Mol file: 438035-23-5.mol

Synonyms:(3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-bis(phenylmethoxy)-1,3-benzodioxole

Chemical Property of (3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-bis(phenylmethoxy)-1,3-benzodioxole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-bis(phenylmethoxy)-1,3-benzodioxole

There total 1 articles about (3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-bis(phenylmethoxy)-1,3-benzodioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + (3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-1,3-benzodioxole-4,7-diol (371155-64-5) → (3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-bis(phenylmethoxy)-1,3-benzodioxole (438035-23-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/jo016237a

Reference yield:

(3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-bis(phenylmethoxy)-1,3-benzodioxole (438035-23-5) → D-5,6-O-(1-methylethylidene)-1,4-bis-O-(phenylmethyl)-myo-inositol (438035-28-0,173828-64-3)

Guidance literature:

With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In acetone; at 20 ℃;

DOI:10.1021/jo016237a

Reference yield:

(3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-4,7-bis(phenylmethoxy)-1,3-benzodioxole (438035-23-5) → C6H10O4(C3H4)O2H2(P(OC7H6)2)2H2(C7H6)2

Guidance literature:

Multi-step reaction with 2 steps

1: NMO / OsO₄ / acetone; H₂O / 12 h / 20 °C

2: 1H-tetrazole / dimethylformamide; CH₂Cl₂ / 7 h / 20 °C

With 1H-tetrazole; N-methyl-2-indolinone; osmium(VIII) oxide; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1080/07328300701540225

upstream raw materials:

benzyl bromide

(3aS,4R,7R,7aS)-3a,4,7,7a-tetrahydro-2,2-dimethyl-1,3-benzodioxole-4,7-diol

Downstream raw materials:

D-5,6-O-(1-methylethylidene)-1,4-bis-O-(phenylmethyl)-myo-inositol

L-1,2:4,5-di-O-isopropylidene-3-O-benzoyl-6-O-benzyl-myo-inositol

L-2-O-benzoyl-6-O-benzyl-myo-inositol

L-2-O-benzoyl-6-O-benzyl-1,3,4,5-tetra-O-methoxymethyl-myo-inositol