(3S,4R)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

Base Information

Chemical Name:(3S,4R)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone
CAS No.:1345966-26-8
Molecular Formula:C₁₇H₁₇F₇INO₂
Molecular Weight:527.221
Hs Code.:

Synonyms:(3S,4R)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

Suppliers and Price of (3S,4R)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4R)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4R)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

There total 5 articles about (3S,4R)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 914498-71-8
N-(phenylmethoxy)-2-methyl-N-(2-propen-1-yl)-2-propenamide

: 754-34-7
1,1,1,2,2,3,3-heptafluoro-3-iodo-propane

: (3R,4S)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

: 1401982-06-6
(3S,4S)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

: 1345966-26-8
(3S,4R)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

Guidance literature:: N-(phenylmethoxy)-2-methyl-N-(2-propen-1-yl)-2-propenamide; With (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

1,1,1,2,2,3,3-heptafluoro-3-iodo-propane; With triethyl borane; In hexane; dichloromethane; toluene; at -78 ℃; for 24h; Reagent/catalyst; Solvent; enantioselective reaction;
DOI:10.1021/jo3015227

Reference yield:

: 122149-19-3
N-allyl-O-benzylhydroxylamine

: (3R,4S)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

: 1345966-26-8
(3S,4R)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2.1: (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.2: 24 h / -78 °C

With (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate; triethylamine; In dichloromethane;
DOI:10.1021/jo3015227

Reference yield:

: 79722-21-7
tert-butyl N-(benzyloxy)carbamate

: (3R,4S)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

: 1345966-26-8
(3S,4R)-3-(2,2,3,3,4,4,4-heptafluorobutyl)-4-(iodomethyl)-3-methyl-1-(phenylmethoxy)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.2: 24 h / -78 °C

With (3aR,3a’R,8aS,8a’S)-2,2’-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]-oxazole); zinc trifluoromethanesulfonate; caesium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo3015227