122149-19-3Relevant academic research and scientific papers
Effect of Substituents and Stability of Transient Aluminum-Aminals in the Presence of Nucleophiles
Barrios, Francis J.,Springer, Brannon C.,Hazlitt, Robert A.,Colby, David A.
, p. 175 - 180 (2015/05/05)
Disubstituted hydroxylamines are synthesized and used to form aluminum-amide complexes. These reagents mask carbonyl groups in situ via nucleophilic addition. The stability and utility of the aluminum-aminals are presented in the context of selectively controlling nucleophilic addition on substrates with multiple carbonyl groups.
Rational design, synthesis, and evaluation of tetrahydroxamic acid chelators for stable complexation of zirconium(IV)
Guerard, Francois,Lee, Yong-Sok,Brechbiel, Martin W.
, p. 5584 - 5591 (2014/05/20)
Metals of interest for biomedical applications often need to be complexed and associated in a stable manner with a targeting agent before use. Whereas the fundamentals of most transition-metal complexation processes have been thoroughly studied, the compl
TETRAHYDROXAMATE CHELATORS OF ZIRCONIUM89 AND NIOBIUM90 FOR USE IN DIAGNOSTIC APPLICATIONS
-
, (2014/10/18)
Disclosed is a compound of formula (I) or (II) in which R1-R4, R1,-R5,, Z1+-Z4, and Z1,-Z4, are as described herein. Also disclosed are a 89Zr- or 90/
Polarity-mismatched addition of electrophilic carbon radicals to an electron-deficient acceptor: Cascade radical addition-cyclization-trapping reaction
Yoshioka, Eito,Kohtani, Shigeru,Sawai, Kaori,Kentefu,Tanaka, Eri,Miyabe, Hideto
, p. 8588 - 8604,17 (2020/09/15)
The polarity-mismatched perfluoroalkyl radical addition to electron-deficient alkenes was studied. For this study, several substrates having two polarity-different radical acceptors were employed to investigate the regiochemical courses of cascade reactio
Lewis acid-mediated radical cyclization: Stereocontrol in cascade radical addition-cyclization-trapping reactions
Miyabe, Hideto,Asada, Ryuta,Takemoto, Yoshiji
supporting information; experimental part, p. 3519 - 3530 (2012/05/20)
An efficient approach for achieving radical cyclizations by using hydroxamate ester as a coordination tether with Lewis acid was studied. The chiral Lewis acid-mediated cascade radical addition-cyclization-trapping reaction proceeded smoothly with good en
Synthesis of the reported structure of the naturally occurring siderophore nocardimicin B
Banks, James C.,Moody, Christopher J.
scheme or table, p. 3371 - 3373 (2009/08/17)
A total synthesis of the reported structure of the naturally occurring siderophore nocardimicin B is reported: the synthetic material appears to be diastereomeric with the natural product.
1-Hydroxy-3-amino-2-piperidone (δ-N-Hydroxycycloornithine) Derivatives: Key Intermediates for the Synthesis of Hydroxamate-Based Siderophores
Kolasa, Teodozyj,Miller, Marvin J.
, p. 1711 - 1721 (2007/10/02)
Several routes for the synthesis of δ-N-(benzyloxy)cycloornithine (2) from glutamic acid derived starting materials are described.Efficient methods were developed for the synthesis of glutamic acid γ-semialdehyde and γ-hydroxynorvaline derivatives as key substrates for the preparation of δ-N-hydroxyornithine analogues.Thus, the best approaches to the synthesis of 2 were: (1) reductive cyclization of an N-hydroxysuccinimide ester of the O-benzyloxime 4 of α-amino-protected glutamic acid γ-semialdehyde 5 and (2) cyclization of the N-(benzyloxy)amide of δ-bromonorvaline (7).
ALKYLATION OF N-BENZYLOXYUREAS AND CARBAMATES
Sulsky, Richard,Demers, James P.
, p. 31 - 34 (2007/10/02)
N-benzyloxyureas and orthogonically protected N-hydroxycarbamates can be alkylated in high yields and subsequently deprotected to provide N-alkyl hydroxyureas and hydroxylamines.
