2-cyano-15-cyclohexyl-2-decarboxy-9-deoxy-13,14-dihydro-2',9α-methano-4,5,6,16,17,18,19,20-octanor-3-oxa-3,7-(1',3'-inter-phenylene)-PFG1

Base Information

Chemical Name:2-cyano-15-cyclohexyl-2-decarboxy-9-deoxy-13,14-dihydro-2',9α-methano-4,5,6,16,17,18,19,20-octanor-3-oxa-3,7-(1',3'-inter-phenylene)-PFG1
CAS No.:99512-00-2
Molecular Formula:C₂₄H₃₃NO₃
Molecular Weight:383.531
Hs Code.:

Synonyms:2-cyano-15-cyclohexyl-2-decarboxy-9-deoxy-13,14-dihydro-2',9α-methano-4,5,6,16,17,18,19,20-octanor-3-oxa-3,7-(1',3'-inter-phenylene)-PFG1

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Chemical Property of 2-cyano-15-cyclohexyl-2-decarboxy-9-deoxy-13,14-dihydro-2',9α-methano-4,5,6,16,17,18,19,20-octanor-3-oxa-3,7-(1',3'-inter-phenylene)-PFG1

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Technology Process of 2-cyano-15-cyclohexyl-2-decarboxy-9-deoxy-13,14-dihydro-2',9α-methano-4,5,6,16,17,18,19,20-octanor-3-oxa-3,7-(1',3'-inter-phenylene)-PFG1

There total 3 articles about 2-cyano-15-cyclohexyl-2-decarboxy-9-deoxy-13,14-dihydro-2',9α-methano-4,5,6,16,17,18,19,20-octanor-3-oxa-3,7-(1',3'-inter-phenylene)-PFG1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 107-14-2
chloroacetonitrile

: 99511-99-6
15-cyclohexyl-1,2,4,5,6,16,17,18,19,20-decanor-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-3,7-(1',3'-inter-phenylene)-PGF1

: 99512-00-2
2-cyano-15-cyclohexyl-2-decarboxy-9-deoxy-13,14-dihydro-2',9α-methano-4,5,6,16,17,18,19,20-octanor-3-oxa-3,7-(1',3'-inter-phenylene)-PFG1

Guidance literature:: With potassium carbonate; In acetone; for 48h; Heating;
DOI:10.1021/ja00312a028

Reference yield:

: 99511-98-5
15-cyclohexyl-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-1,4,5,6,16,17,18,19,20-nonanor-3,7-(1',3'-inter-phenylene)-PGF1

: 99512-00-2
2-cyano-15-cyclohexyl-2-decarboxy-9-deoxy-13,14-dihydro-2',9α-methano-4,5,6,16,17,18,19,20-octanor-3-oxa-3,7-(1',3'-inter-phenylene)-PFG1

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / n-butyllithium / 1.) THF, hexane, 0 deg C, 5 min then 25 deg C, 30 min; reflux, 5.5 h; hexane, reflux, 18 h

2: 91 percent / anhydrous potassium carbonate / acetone / 48 h / Heating

With n-butyllithium; potassium carbonate; In acetone;
DOI:10.1021/ja00312a028

Reference yield:

: 1-[(R)-3-Cyclohexyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol

: 99512-00-2
2-cyano-15-cyclohexyl-2-decarboxy-9-deoxy-13,14-dihydro-2',9α-methano-4,5,6,16,17,18,19,20-octanor-3-oxa-3,7-(1',3'-inter-phenylene)-PFG1

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / gl. acetic acid / tetrahydrofuran; H₂O / 3 h / 45 °C

2: 96 percent / n-butyllithium / 1.) THF, hexane, 0 deg C, 5 min then 25 deg C, 30 min; reflux, 5.5 h; hexane, reflux, 18 h

3: 91 percent / anhydrous potassium carbonate / acetone / 48 h / Heating

With n-butyllithium; potassium carbonate; acetic acid; In tetrahydrofuran; water; acetone;
DOI:10.1021/ja00312a028