15-cyclohexyl-1,2,4,5,6,16,17,18,19,20-decanor-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-3,7-(1',3'-inter-phenylene)-PGF1

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Chemical Name:15-cyclohexyl-1,2,4,5,6,16,17,18,19,20-decanor-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-3,7-(1',3'-inter-phenylene)-PGF1
CAS No.:99511-99-6
Molecular Formula:C₂₂H₃₂O₃
Molecular Weight:344.494
Hs Code.:

Synonyms:15-cyclohexyl-1,2,4,5,6,16,17,18,19,20-decanor-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-3,7-(1',3'-inter-phenylene)-PGF1

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Chemical Property of 15-cyclohexyl-1,2,4,5,6,16,17,18,19,20-decanor-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-3,7-(1',3'-inter-phenylene)-PGF1

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Technology Process of 15-cyclohexyl-1,2,4,5,6,16,17,18,19,20-decanor-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-3,7-(1',3'-inter-phenylene)-PGF1

There total 2 articles about 15-cyclohexyl-1,2,4,5,6,16,17,18,19,20-decanor-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-3,7-(1',3'-inter-phenylene)-PGF1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 99511-98-5
15-cyclohexyl-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-1,4,5,6,16,17,18,19,20-nonanor-3,7-(1',3'-inter-phenylene)-PGF1

: 829-85-6
diphenylphosphane

: 99511-99-6
15-cyclohexyl-1,2,4,5,6,16,17,18,19,20-decanor-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-3,7-(1',3'-inter-phenylene)-PGF1

Guidance literature:: With n-butyllithium; 1.) THF, hexane, 0 deg C, 5 min then 25 deg C, 30 min; reflux, 5.5 h; hexane, reflux, 18 h;
DOI:10.1021/ja00312a028

Reference yield:

: 1-[(R)-3-Cyclohexyl-3-(tetrahydro-pyran-2-yloxy)-propyl]-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol

: 99511-99-6
15-cyclohexyl-1,2,4,5,6,16,17,18,19,20-decanor-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-3,7-(1',3'-inter-phenylene)-PGF1

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / gl. acetic acid / tetrahydrofuran; H₂O / 3 h / 45 °C

2: 96 percent / n-butyllithium / 1.) THF, hexane, 0 deg C, 5 min then 25 deg C, 30 min; reflux, 5.5 h; hexane, reflux, 18 h

With n-butyllithium; acetic acid; In tetrahydrofuran; water;
DOI:10.1021/ja00312a028