3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline

Base Information

• Chemical Name: 3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline
• CAS No.: 1318918-66-9
• Molecular Formula: C₂₅H₂₆ClN₃O₆S
• Molecular Weight: 532.017
• Mol file: 1318918-66-9.mol

Synonyms:3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline

Chemical Property of 3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline

There total 2 articles about 3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

C19H19ClO5 (165612-81-7) + 4-hydrazinobenzene-1-sulfonamide hydrochloride (17852-52-7,27918-19-0) → 3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline (1318918-66-9)

Guidance literature:

In ethanol; for 24h; Reflux;

DOI:10.1016/j.bmcl.2011.05.061

Reference yield:

5'-chloro-2'-hydroxy-4'-methyl acetophenone (28480-70-8) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → 3-(5'-chloro-2'-hydroxy-4'-methylphenyl)-5-(3,4,5-trimethoxyphenyl)-1-(p-sulfamylphenyl)-Δ(2)-pyrazoline (1318918-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 10 °C

2: ethanol / 24 h / Reflux

With sodium hydroxide; In ethanol; 1: Claisen Schmidt condensation;

DOI:10.1016/j.bmcl.2011.05.061

upstream raw materials:

C₁₉H₁₉ClO₅

4-hydrazinobenzene-1-sulfonamide hydrochloride

5'-chloro-2'-hydroxy-4'-methyl acetophenone

3,4,5-trimethoxy-benzaldehyde