5'-O-(tert-butyldimethylsilyl)-N²-(4-methoxytrityl)-3'-O-benzoyl-2'-C-methylguanosine

Base Information

• Chemical Name: 5'-O-(tert-butyldimethylsilyl)-N²-(4-methoxytrityl)-3'-O-benzoyl-2'-C-methylguanosine
• CAS No.: 1449760-07-9
• Molecular Formula: C₄₄H₄₉N₅O₇Si
• Molecular Weight: 787.988

Synonyms:5'-O-(tert-butyldimethylsilyl)-N²-(4-methoxytrityl)-3'-O-benzoyl-2'-C-methylguanosine

Chemical Property of 5'-O-(tert-butyldimethylsilyl)-N²-(4-methoxytrityl)-3'-O-benzoyl-2'-C-methylguanosine

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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Technology Process of 5'-O-(tert-butyldimethylsilyl)-N²-(4-methoxytrityl)-3'-O-benzoyl-2'-C-methylguanosine

There total 4 articles about 5'-O-(tert-butyldimethylsilyl)-N²-(4-methoxytrityl)-3'-O-benzoyl-2'-C-methylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(tert-butyldimethylsilyl)-N2-(4-methoxytrityl)-2'-C-methylguanosine (1390625-40-7) + benzoyl chloride (98-88-4) → 5'-O-(tert-butyldimethylsilyl)-N2-(4-methoxytrityl)-3'-O-benzoyl-2'-C-methylguanosine (1449760-07-9)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; Cooling with ice;

DOI:10.3998/ark.5550190.0013.520

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 5'-O-(tert-butyldimethylsilyl)-N2-(4-methoxytrityl)-3'-O-benzoyl-2'-C-methylguanosine (1449760-07-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 24 h / 20 °C

2: pyridine / 20 h / 57 °C

3: pyridine / dichloromethane / 20 °C / Cooling with ice

With pyridine; In dichloromethane;

DOI:10.3998/ark.5550190.0013.520

Reference yield:

C17H29N5O5Si → 5'-O-(tert-butyldimethylsilyl)-N2-(4-methoxytrityl)-3'-O-benzoyl-2'-C-methylguanosine (1449760-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 20 h / 57 °C

2: pyridine / dichloromethane / 20 °C / Cooling with ice

With pyridine; In dichloromethane;

DOI:10.3998/ark.5550190.0013.520

upstream raw materials:

tert-butyldimethylsilyl chloride

2'-C-methylguanosine

5'-O-(tert-butyldimethylsilyl)-N²-(4-methoxytrityl)-2'-C-methylguanosine

benzoyl chloride

Downstream raw materials:

N²-(4-methoxytrityl)-3'-O-benzoyl-2'-C-methylguanosine

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