5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

Base Information

• Chemical Name: 5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one
• CAS No.: 1442451-91-3
• Molecular Formula: C₂₇H₂₅ClF₂N₄O₃
• Molecular Weight: 526.97
• Mol file: 1442451-91-3.mol

Synonyms:5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

Chemical Property of 5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

There total 12 articles about 5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one (1442451-92-4) + 1-chloromethyl-2,4-difluoro-5-methyl-benzene (1378674-68-0) → 5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one (1442451-91-3)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

Reference yield:

2,4-difluoro-5-methyl-benzoic acid methyl ester (1162674-66-9) → 5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one (1442451-91-3)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 °C / Cooling with acetone-dry ice

2: thionyl chloride / dichloromethane / 3 h / 60 °C / Cooling with ice

3: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 5 h / 60 °C

With lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(2,4-difluoro-5-methyl-phenyl)-methanol (315204-46-7) → 5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one (1442451-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 3 h / 60 °C / Cooling with ice

2: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 5 h / 60 °C

With thionyl chloride; 18-crown-6 ether; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2,4-Difluoro-5-methylbenzoic acid

2,4-difluoro-5-methyl-benzoic acid methyl ester

(2,4-difluoro-5-methyl-phenyl)-methanol

5-chloro-6-hydroxy-3-{5-[2-(1-hydroxy-1-methyl-ethyl)-pyrimidin-4-yl]-2-methyl-phenyl}-2-methyl-3H-pyrimidin-4-one