Technology Process of 5-methyl-6-(propan-2-yl)-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one
There total 8 articles about 5-methyl-6-(propan-2-yl)-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium carbonate; potassium iodide;
In
N,N-dimethyl-formamide;
for 22.5h;
Ambient temperature;
DOI:10.1021/jm00106a040
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1 h / Heating
2: Na2CO3 / butan-1-ol / 1.5 h / Heating
3: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating
4: lithium aluminum hydride, conc. H2SO4 / tetrahydrofuran / 24 h
5: 71 percent / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 1 h
6: 87 percent / H2 / 10percent Pd/C / acetic acid / 6 h / 42 °C / 3102.9 Torr
7: 15 percent / potassium iodide, sodium carbonate / dimethylformamide / 22.5 h / Ambient temperature
With
2-hydroxypyridin; lithium aluminium tetrahydride; sulfuric acid; hydrogen; sodium carbonate; potassium iodide;
palladium on activated charcoal;
In
tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; xylene; butan-1-ol;
DOI:10.1021/jm00106a040
- Guidance literature:
-
Multi-step reaction with 8 steps
1: thionyl chloride / toluene / 2 h / Heating
2: 1 h / Heating
3: Na2CO3 / butan-1-ol / 1.5 h / Heating
4: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating
5: lithium aluminum hydride, conc. H2SO4 / tetrahydrofuran / 24 h
6: 71 percent / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 1 h
7: 87 percent / H2 / 10percent Pd/C / acetic acid / 6 h / 42 °C / 3102.9 Torr
8: 15 percent / potassium iodide, sodium carbonate / dimethylformamide / 22.5 h / Ambient temperature
With
2-hydroxypyridin; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; hydrogen; sodium carbonate; potassium iodide;
palladium on activated charcoal;
In
tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; toluene; xylene; butan-1-ol;
DOI:10.1021/jm00106a040
