diethyl (((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)methyl)phosphonate

Base Information

• Chemical Name: diethyl (((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)methyl)phosphonate
• CAS No.: 1354894-24-8
• Molecular Formula: C₁₄H₁₉O₆PS
• Molecular Weight: 346.341
• Mol file: 1354894-24-8.mol

Synonyms:diethyl (((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)methyl)phosphonate

Chemical Property of diethyl (((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)methyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)methyl)phosphonate

There total 1 articles about diethyl (((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

propargyl bromide (106-96-7) + 4-hydroxy-thiophenyl-methyl-diethylphosphonate sulfone (211518-82-0) → diethyl (((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)methyl)phosphonate (1354894-24-8)

Guidance literature:

4-hydroxy-thiophenyl-methyl-diethylphosphonate sulfone; With potassium carbonate; In acetone; at 20 ℃; for 2h; Inert atmosphere;

propargyl bromide; In acetone; toluene; for 12h; Inert atmosphere;

DOI:10.1039/c1cc16178d

Reference yield: 75.0%

diethyl (((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)methyl)phosphonate (1354894-24-8) + (S)-tert-butyl (1-oxo-4-phenylbutan-2-yl)carbamate (170112-07-9) → (S,E)-tert-butyl (5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)carbamate (1354894-25-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; Inert atmosphere;

DOI:10.1039/c1cc16178d

Reference yield:

diethyl (((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)methyl)phosphonate (1354894-24-8) → (S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-amine trifluoroacetate (1354894-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / Inert atmosphere

2: dichloromethane / 2 h / 0 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1039/c1cc16178d

upstream raw materials:

propargyl bromide

4-hydroxy-thiophenyl-methyl-diethylphosphonate sulfone

Downstream raw materials:

(S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-amine trifluoroacetate

N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)amino)propan-2-yl)morpholine-4-carboxamide

(S,E)-tert-butyl (5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)carbamate