N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)amino)propan-2-yl)morpholine-4-carboxamide

Base Information

Chemical Name:N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)amino)propan-2-yl)morpholine-4-carboxamide
CAS No.:1354894-18-0
Molecular Formula:C₃₄H₃₇N₃O₆S
Molecular Weight:615.75
Hs Code.:

Synonyms:N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)amino)propan-2-yl)morpholine-4-carboxamide

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Chemical Property of N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)amino)propan-2-yl)morpholine-4-carboxamide

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Technology Process of N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)amino)propan-2-yl)morpholine-4-carboxamide

There total 10 articles about N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)amino)propan-2-yl)morpholine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1354894-27-1
(S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-amine trifluoroacetate

: 114457-62-4
Nα-(4-morpholinecarbonyl)-L-phenylalanine

: 1354894-18-0
N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)amino)propan-2-yl)morpholine-4-carboxamide

Guidance literature:: Nα-(4-morpholinecarbonyl)-L-phenylalanine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

(S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-amine trifluoroacetate; In N,N-dimethyl-formamide; at 20 ℃; for 21h; Inert atmosphere;
DOI:10.1039/c1cc16178d

Reference yield:

: 2462-32-0
L-phenylalanine benzyl ester hydrochloride

: 1354894-18-0
N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)amino)propan-2-yl)morpholine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 0.25 h / 0 °C / Inert atmosphere

2.1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 12 h / 2585.81 Torr

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

4.2: 21 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c1cc16178d

Reference yield:

: (S)-benzyl 2-(morpholine-4-carboxamido)-3-phenylpropanoate

: 1354894-18-0
N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-((4-(prop-2-yn-1-yloxy)phenyl)sulfonyl)pent-1-en-3-yl)amino)propan-2-yl)morpholine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 12 h / 2585.81 Torr

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 21 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c1cc16178d