4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoic acid

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Chemical Name:4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoic acid
CAS No.:1393126-62-9
Molecular Formula:C₂₃H₂₁F₃N₂O₂
Molecular Weight:414.427
Hs Code.:

Synonyms:4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoic acid

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Chemical Property of 4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoic acid

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Technology Process of 4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoic acid

There total 5 articles about 4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1393126-61-8
methyl 4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoate

: 1393126-62-9
4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoic acid

Guidance literature:: methyl 4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoate; With methanol; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 60h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=2;

Reference yield:

: 1571-08-0
methyl 4-formylbenzoate

: 1393126-62-9
4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0 - 20 °C

2.1: pyridinium chlorochromate / dichloromethane / 48 h / 0 - 20 °C

3.1: lithium hexamethyldisilazane / toluene / 1 h / 0 - 20 °C

3.2: 18 h

4.1: potassium carbonate / copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 18 h / 90 °C / Inert atmosphere

5.1: sodium hydroxide; methanol / tetrahydrofuran / 60 h / 20 °C

5.2: pH 2

With methanol; potassium carbonate; pyridinium chlorochromate; sodium hydroxide; lithium hexamethyldisilazane; copper(l) iodide; 8-quinolinol; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; 1.1: Grignard Reaction;

Reference yield:

: 100757-91-3
1-(p-methoxycarbonylphenyl)-3-methyl-1-butanol

: 1393126-62-9
4-(4-methyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)pent-1-en-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium chlorochromate / dichloromethane / 48 h / 0 - 20 °C

2.1: lithium hexamethyldisilazane / toluene / 1 h / 0 - 20 °C

2.2: 18 h

3.1: potassium carbonate / copper(l) iodide; 8-quinolinol / dimethyl sulfoxide / 18 h / 90 °C / Inert atmosphere

4.1: sodium hydroxide; methanol / tetrahydrofuran / 60 h / 20 °C

4.2: pH 2

With methanol; potassium carbonate; pyridinium chlorochromate; sodium hydroxide; lithium hexamethyldisilazane; copper(l) iodide; 8-quinolinol; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;