2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperazinyl)methyl]-5-benzofuranamine

Base Information

Chemical Name:2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperazinyl)methyl]-5-benzofuranamine
CAS No.:142873-40-3
Molecular Formula:C₂₃H₃₁N₃O
Molecular Weight:365.519
Hs Code.:

Synonyms:2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperazinyl)methyl]-5-benzofuranamine

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Chemical Property of 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperazinyl)methyl]-5-benzofuranamine

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Technology Process of 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperazinyl)methyl]-5-benzofuranamine

There total 5 articles about 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperazinyl)methyl]-5-benzofuranamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 92-54-6
4-phenyl-1-piperazine

: 142873-74-3
N-(2-bromomethyl-2,3-dihydro-2,4,6,7-tetramethylbenzofuran-5-yl)formamide

: 142873-40-3
2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperazinyl)methyl]-5-benzofuranamine

Guidance literature:: at 180 ℃; for 18h;
DOI:10.1021/jm960411j

Reference yield: 18.3%

: 142873-40-3
2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperazinyl)methyl]-5-benzofuranamine

Guidance literature:

Reference yield:

: 99075-42-0
N-(4-hydroxy-2,3,6-trimethylphenyl)-formamide

: 142873-40-3
2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperazinyl)methyl]-5-benzofuranamine

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / K₂CO₃ / dimethylformamide / 3 h / 80 °C

2: 94 percent / N,N-diethylaniline / 3 h / 200 °C

3: 81 percent / Br₂, NaOAc / acetic acid / 0.17 h / Ambient temperature

4: 75 percent / 18 h / 180 °C

With bromine; sodium acetate; potassium carbonate; N,N-diethylaniline; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm960411j