(2S)-N-[5-benzyloxy-2-[(S)-2-(methoxycarbonyl)amino-3-hydroxypropyl]phenyl]valine benzyl ester

Base Information

Chemical Name:(2S)-N-[5-benzyloxy-2-[(S)-2-(methoxycarbonyl)amino-3-hydroxypropyl]phenyl]valine benzyl ester
CAS No.:215300-59-7
Molecular Formula:C₃₀H₃₆N₂O₆
Molecular Weight:520.626
Hs Code.:

Synonyms:(2S)-N-[5-benzyloxy-2-[(S)-2-(methoxycarbonyl)amino-3-hydroxypropyl]phenyl]valine benzyl ester

Suppliers and Price of (2S)-N-[5-benzyloxy-2-[(S)-2-(methoxycarbonyl)amino-3-hydroxypropyl]phenyl]valine benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-N-[5-benzyloxy-2-[(S)-2-(methoxycarbonyl)amino-3-hydroxypropyl]phenyl]valine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-N-[5-benzyloxy-2-[(S)-2-(methoxycarbonyl)amino-3-hydroxypropyl]phenyl]valine benzyl ester

There total 13 articles about (2S)-N-[5-benzyloxy-2-[(S)-2-(methoxycarbonyl)amino-3-hydroxypropyl]phenyl]valine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 131423-64-8
benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate

: 215300-57-5
[(S)-2-(2-Amino-4-benzyloxy-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid methyl ester

: 215300-59-7
(2S)-N-[5-benzyloxy-2-[(S)-2-(methoxycarbonyl)amino-3-hydroxypropyl]phenyl]valine benzyl ester

Guidance literature:: With lutidine; In 1,2-dichloro-ethane; at 70 ℃;
DOI:10.1016/S0040-4039(98)01598-6

Reference yield:

: 1080-06-4
L-Tyr-OMe

: 215300-59-7
(2S)-N-[5-benzyloxy-2-[(S)-2-(methoxycarbonyl)amino-3-hydroxypropyl]phenyl]valine benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / NaOH; NaHCO₃ / H₂O; CHCl₃ / 2 h

2: 85 percent / La(NO₃)2*6H₂O; NaNO₃; 6N HCl / CH₂Cl₂ / 6 h / 0 - 20 °C

3: H₂ / Pd/C / ethyl acetate / 22800 Torr

4: 80 percent / Et₃N / CH₂Cl₂ / 2 h / -10 °C

5: LiBH₄ / tetrahydrofuran / 5 h / 20 °C

6: 78 percent / pyridine / 8 h / 20 °C

7: 61 percent

8: 90 percent / K₂CO₃ / dimethylformamide / 2 h / 50 °C

9: Cu(OAc)2; NaBH₄ / methanol / 0.5 h / 0 °C

10: 64 percent / 2,6-lutidine / 1,2-dichloro-ethane / 72 h / 70 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium hydroxide; sodium nitrate; sodium tetrahydroborate; lithium borohydride; copper diacetate; lanthanum nitrate; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; chloroform; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: NH2-protection / 2: Nitration / 3: Reduction / 4: Acetylation / 5: Reduction / 6: Acetylation / 8: Substitution / 9: Reduction / 10: Substitution;
DOI:10.1021/jo990605h

Reference yield:

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 215300-59-7
(2S)-N-[5-benzyloxy-2-[(S)-2-(methoxycarbonyl)amino-3-hydroxypropyl]phenyl]valine benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: SOCl₂ / Heating

2: 100 percent / NaOH; NaHCO₃ / H₂O; CHCl₃ / 2 h

3: 85 percent / La(NO₃)2*6H₂O; NaNO₃; 6N HCl / CH₂Cl₂ / 6 h / 0 - 20 °C

4: H₂ / Pd/C / ethyl acetate / 22800 Torr

5: 80 percent / Et₃N / CH₂Cl₂ / 2 h / -10 °C

6: LiBH₄ / tetrahydrofuran / 5 h / 20 °C

7: 78 percent / pyridine / 8 h / 20 °C

8: 61 percent

9: 90 percent / K₂CO₃ / dimethylformamide / 2 h / 50 °C

10: Cu(OAc)2; NaBH₄ / methanol / 0.5 h / 0 °C

11: 64 percent / 2,6-lutidine / 1,2-dichloro-ethane / 72 h / 70 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium hydroxide; sodium nitrate; sodium tetrahydroborate; lithium borohydride; thionyl chloride; copper diacetate; lanthanum nitrate; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; chloroform; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: Esterification / 2: NH2-protection / 3: Nitration / 4: Reduction / 5: Acetylation / 6: Reduction / 7: Acetylation / 9: Substitution / 10: Reduction / 11: Substitution;
DOI:10.1021/jo990605h