benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate

Base Information

• Chemical Name: benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate
• CAS No.: 131423-64-8
• Molecular Formula: C₁₃H₁₅F₃O₅S
• Molecular Weight: 340.32
• Mol file: 131423-64-8.mol

Synonyms:benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate

Chemical Property of benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate

There total 3 articles about benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trifluoromethylsulfonic anhydride (358-23-6) + benzyl (R)-2-hydroxy-3-methylbutanoate (2441-07-8,65138-05-8,14487-24-2) → benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate (131423-64-8)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)87853-4

Reference yield:

D-Val-OH (640-68-6,25609-85-2,7004-03-7,921-10-8) → benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate (131423-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NaNO₂, 1N H₂SO₄ / H₂O / 1.) 0 deg C, 2.) 0 deg C to room temperature, 12 h

2: 78 percent / SOCl₂ / benzene / 40 h / Heating

3: 99 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

With 2,6-dimethylpyridine; thionyl chloride; sulfuric acid; sodium nitrite; In dichloromethane; water; benzene;

DOI:10.1016/S0040-4020(01)87853-4

Reference yield:

(R)-2-Hydroxy-3-methylbutyric acid (17407-56-6) → benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate (131423-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / SOCl₂ / benzene / 40 h / Heating

2: 99 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

With 2,6-dimethylpyridine; thionyl chloride; In dichloromethane; benzene;

DOI:10.1016/S0040-4020(01)87853-4

upstream raw materials:

trifluoromethylsulfonic anhydride

benzyl (R)-2-hydroxy-3-methylbutanoate

D-Val-OH

(R)-2-Hydroxy-3-methylbutyric acid

Downstream raw materials:

(S)-2-((S)-3-Isopropyl-2-oxo-morpholin-4-yl)-3-methyl-butyric acid benzyl ester

(S)-4-(methyl(1-(((phenylmethyl)oxy)carbonyl)-2-methylpropyl)amino)-6,7-(1,2,3,4-tetrahydro-1,1,4,4-tetramethylbenzo)indole

(S,S)-(2-(4-((1-(((phenylmethyl)oxy)carbonyl)-2-methylpropyl)amino)-1H-indol-3-yl)-1-(hydroxymethyl)ethyl)carbamic acid, phenylmethyl ester