(1S)-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucitol

Base Information

• Chemical Name: (1S)-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucitol
• CAS No.: 1240304-72-6
• Molecular Formula: C₂₈H₅₅BrO₆Si₄
• Molecular Weight: 679.987
• Mol file: 1240304-72-6.mol

Synonyms:(1S)-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucitol

Chemical Property of (1S)-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucitol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S)-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucitol

There total 13 articles about (1S)-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + C16H23BrO6 → (1S)-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucitol (1240304-72-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 4 - 20 ℃; Inert atmosphere;

Reference yield:

triethylsilane (617-86-7) + (1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol (1240304-71-5) → (1S)-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucitol (1240304-72-6)

Guidance literature:

(1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol; With sodium methylate; In methanol; at 20 ℃; for 2h;

triethylsilane; With triethylamine; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 2h; Cooling with ice;

Reference yield:

chloro-trimethyl-silane (75-77-4) + (1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol (1240304-71-5) → (1S)-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glucitol (1240304-72-6)

Guidance literature:

(1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol; With sodium methylate; In methanol; at 20 ℃; for 2h;

chloro-trimethyl-silane; With triethylamine; In N,N-dimethyl-formamide; at 4 - 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

(1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-[2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol

triethylsilane

(1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-[5-bromo-2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol

2-iodo-5-(propan-2-yl)phenol

Downstream raw materials:

(1S)-2,3,4,6-tetra-O-acetyl-1,5-anhydro-1-{5-[(4-bromophenyl)methyl]-2-methoxy-4-(propan-2-yl)phenyl}-D-glucitol

C₄₁H₅₃NO₁₃

C₄₅H₆₃N₃O₁₂

(E)-N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-isopropyl-4-methoxy-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-2,2-dimethylbut-3-enamide