1-((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carbonyl)piperidin-4-one

Base Information

Chemical Name:1-((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carbonyl)piperidin-4-one
CAS No.:1173565-58-6
Molecular Formula:C₂₅H₂₈N₂O₅
Molecular Weight:436.508
Hs Code.:

Synonyms:1-((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carbonyl)piperidin-4-one

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Chemical Property of 1-((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carbonyl)piperidin-4-one

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Technology Process of 1-((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carbonyl)piperidin-4-one

There total 2 articles about 1-((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carbonyl)piperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1173565-56-4
(3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid

: 40064-34-4
piperidine-4,4-diol hydrochloride

: 1173565-58-6
1-((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carbonyl)piperidin-4-one

Guidance literature:: (3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

piperidine-4,4-diol hydrochloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 72.0%

: 1173565-56-4
(3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid

: 41979-39-9
4-piperidone hydrochloride

: 1173565-58-6
1-((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carbonyl)piperidin-4-one

Guidance literature:: (3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

4-piperidone hydrochloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

Reference yield:

: 1173565-58-6
1-((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carbonyl)piperidin-4-one

: 1173898-75-3
1-(((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-1-((R)-1-phenylethyl)pyrrolidin-3-yl)methyl)piperidin-4-ol

Guidance literature:: 1-((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carbonyl)piperidin-4-one; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Heating; Reflux;

With water; sodium hydroxide; In tetrahydrofuran;