(3S,4R)-4-(3-fluorophenyl)-4-hydroxy-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid

Base Information

Chemical Name:(3S,4R)-4-(3-fluorophenyl)-4-hydroxy-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid
CAS No.:1173565-56-4
Molecular Formula:C₂₀H₂₁NO₅
Molecular Weight:355.39
Hs Code.:
Mol file:1173565-56-4.mol

Synonyms:(3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid

Suppliers and Price of (3S,4R)-4-(3-fluorophenyl)-4-hydroxy-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4R)-4-(3-fluorophenyl)-4-hydroxy-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (3S,4R)-4-(3-fluorophenyl)-4-hydroxy-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid

There total 2 articles about (3S,4R)-4-(3-fluorophenyl)-4-hydroxy-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1173565-53-1
(3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

: 1173565-56-4
(3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid

Guidance literature:: (3R,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate; With water; sodium hydroxide; In methanol; at 20 ℃; for 6h;

With hydrogenchloride; In water;

Reference yield: 83.0%

: (3S,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate

: 1173565-56-4
(3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid

Guidance literature:: (3S,4R)-methyl 4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylate; With methanol; sodium hydroxide; at 20 ℃; for 6h;

With hydrogenchloride; water; In methanol;

Reference yield: 72.0%

: 1173565-56-4
(3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid

: 40064-34-4
piperidine-4,4-diol hydrochloride

: 1173565-58-6
1-((3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carbonyl)piperidin-4-one

Guidance literature:: (3S,4R)-4-hydroxy-4-(4-methoxyphenyl)-5-oxo-1-((R)-1-phenylethyl)pyrrolidine-3-carboxylic acid; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

piperidine-4,4-diol hydrochloride; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;