S,S-diphenyl 3'-O-dianilinophosphinyl-5'-O-(4-methoxytrityl)-6-N-benzoyladenosine 2'-phosphorothioate

Base Information

Chemical Name:S,S-diphenyl 3'-O-dianilinophosphinyl-5'-O-(4-methoxytrityl)-6-N-benzoyladenosine 2'-phosphorothioate
CAS No.:116113-62-3
Molecular Formula:C₆₁H₅₃N₇O₈P₂S₂
Molecular Weight:1138.21
Hs Code.:

Synonyms:S,S-diphenyl 3'-O-dianilinophosphinyl-5'-O-(4-methoxytrityl)-6-N-benzoyladenosine 2'-phosphorothioate

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Chemical Property of S,S-diphenyl 3'-O-dianilinophosphinyl-5'-O-(4-methoxytrityl)-6-N-benzoyladenosine 2'-phosphorothioate

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Technology Process of S,S-diphenyl 3'-O-dianilinophosphinyl-5'-O-(4-methoxytrityl)-6-N-benzoyladenosine 2'-phosphorothioate

There total 8 articles about S,S-diphenyl 3'-O-dianilinophosphinyl-5'-O-(4-methoxytrityl)-6-N-benzoyladenosine 2'-phosphorothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 67941-87-1
cyclohexylammonium S,S-diphenyl phosphorodithioate

: C₄₉H₄₄N₇O₇P

: 116113-62-3
S,S-diphenyl 3'-O-dianilinophosphinyl-5'-O-(4-methoxytrityl)-6-N-benzoyladenosine 2'-phosphorothioate

Guidance literature:: With 1H-tetrazole; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; In pyridine; for 0.25h;
DOI:10.1246/bcsj.64.588

Reference yield:

: 97997-66-5
N⁶-benzoyladenosine 3'-phosphorodianilidate

: 116113-62-3
S,S-diphenyl 3'-O-dianilinophosphinyl-5'-O-(4-methoxytrityl)-6-N-benzoyladenosine 2'-phosphorothioate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 3 h

2: mesitylenedisulfonyl chloride, tetrazole / 0.25 h

With 1H-tetrazole; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; In pyridine;
DOI:10.1016/S0040-4039(00)96815-1

Reference yield:

: 79154-57-7
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

: 116113-62-3
S,S-diphenyl 3'-O-dianilinophosphinyl-5'-O-(4-methoxytrityl)-6-N-benzoyladenosine 2'-phosphorothioate

Guidance literature:: Multi-step reaction with 6 steps

1: tetrazole / 1,2-dichloro-ethane / 0.17 h

2: tetrazole / 1,2-dichloro-ethane / 0.17 h

3: iodine, pyridine / CH₂Cl₂ / 0.17 h

4: 56 percent / KF, Et₄NBr / acetonitrile; H₂O / 0.33 h / 45 °C

5: pyridine / 3 h

6: 83 percent / tetrazole, mesitylenedisulfonyl dichloride (MDS) / pyridine / 0.25 h

With pyridine; 1H-tetrazole; potassium fluoride; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; tetraethylammonium bromide; iodine; In pyridine; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1246/bcsj.64.588