(1S,2S)-2-Amino-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)propan-1-ol

Base Information

• Chemical Name: (1S,2S)-2-Amino-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)propan-1-ol
• CAS No.: 877078-87-0
• Molecular Formula: C₂₆H₂₈F₂N₂O₂
• Molecular Weight: 438.517

Synonyms:(1S,2S)-2-Amino-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)propan-1-ol

Chemical Property of (1S,2S)-2-Amino-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)propan-1-ol

Chemical Property:

Purity/Quality:

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Technology Process of (1S,2S)-2-Amino-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)propan-1-ol

There total 1 articles about (1S,2S)-2-Amino-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S,5S)-4-(3,5-difluorobenzyl)-5-((R)-4-benzhydrylmorpholin-3-yl)oxazolidin-2-one (877078-86-9) → (1S,2S)-2-Amino-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)propan-1-ol (877078-87-0)

Guidance literature:

With lithium hydroxide; ethanol; water; at 98 ℃;

Reference yield:

(1S,2S)-2-Amino-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)propan-1-ol (877078-87-0) + N,N-Dipropylisophthalamic acid (126926-35-0) → N1-((1S,2S)-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-N3,N3-dipropylisophthalamide (910447-89-1)

Guidance literature:

N,N-Dipropylisophthalamic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 0.333333h;

(1S,2S)-2-Amino-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)propan-1-ol; In dichloromethane; at 20 ℃;

Reference yield:

(S)-2-((S)-3-acetamido-3-((S)-sec-butyl)-2-oxopyrrolidin-1-yl)-4-phenylbutanoic acid (658691-36-2) + (1S,2S)-2-Amino-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)propan-1-ol (877078-87-0) → (S)-2-((S)-3-acetamido-3-((S)-sec-butyl)-2-oxopyrrolidin-1-yl)-N-((1S,2S)-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-4-phenylbutanamide (877079-38-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane;

upstream raw materials:

(4S,5S)-4-(3,5-difluorobenzyl)-5-((R)-4-benzhydrylmorpholin-3-yl)oxazolidin-2-one

Downstream raw materials:

(S)-2-((S)-3-acetamido-3-((S)-sec-butyl)-2-oxopyrrolidin-1-yl)-N-((1S,2S)-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-4-phenylbutanamide

N₁-((1S,2S)-1-((R)-4-benzhydrylmorpholin-3-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-N₃,N₃-dipropylisophthalamide

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