2-{(adamantan-1-yloxy)-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid

Base Information

Chemical Name:2-{(adamantan-1-yloxy)-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid
CAS No.:237394-58-0
Molecular Formula:C₄₅H₅₀NO₆P
Molecular Weight:731.869
Hs Code.:

2-{(adamantan-1-yloxy)-[1-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid

Synonyms:2-{(adamantan-1-yloxy)-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid

Suppliers and Price of 2-{(adamantan-1-yloxy)-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{(adamantan-1-yloxy)-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-{(adamantan-1-yloxy)-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid

There total 6 articles about 2-{(adamantan-1-yloxy)-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27356-88-3
ethyl 2-methylene-5-phenylpentanoate

: 237394-58-0
2-{(adamantan-1-yloxy)-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) hexamethyldisilazane / 1.) 110 deg C, 1 h, 2.) 110 deg C, 3 h

2: 75 percent / silver oxide / CHCl₃ / 0.5 h / Heating

3: 97 percent / 4N aq. NaOH / methanol / 18 h

4: ammonium formate / 10 percent Pd/C / methanol / 0.2 h / Ambient temperature

5: aq. Na₂CO₃ / dioxane / 1.) 4 deg C, 2 h, 2.) RT, 4 h

With sodium hydroxide; ammonium formate; sodium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform;
DOI:10.1021/jm9900164

Reference yield:

: 115961-49-4
[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid

: 237394-58-0
2-{(adamantan-1-yloxy)-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) hexamethyldisilazane / 1.) 110 deg C, 1 h, 2.) 110 deg C, 3 h

2: 75 percent / silver oxide / CHCl₃ / 0.5 h / Heating

3: 97 percent / 4N aq. NaOH / methanol / 18 h

4: ammonium formate / 10 percent Pd/C / methanol / 0.2 h / Ambient temperature

5: aq. Na₂CO₃ / dioxane / 1.) 4 deg C, 2 h, 2.) RT, 4 h

With sodium hydroxide; ammonium formate; sodium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform;
DOI:10.1021/jm9900164

Reference yield:

: 237394-24-0
2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-5-phenyl-pentanoic acid ethyl ester

: 237394-58-0
2-{(adamantan-1-yloxy)-[1-(9H-fluoren-9-ylmethoxycarbonylamino)-2-phenyl-ethyl]-phosphinoylmethyl}-5-phenyl-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / silver oxide / CHCl₃ / 0.5 h / Heating

2: 97 percent / 4N aq. NaOH / methanol / 18 h

3: ammonium formate / 10 percent Pd/C / methanol / 0.2 h / Ambient temperature

4: aq. Na₂CO₃ / dioxane / 1.) 4 deg C, 2 h, 2.) RT, 4 h

With sodium hydroxide; ammonium formate; sodium carbonate; silver(l) oxide; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform;
DOI:10.1021/jm9900164