methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Base Information

Chemical Name:methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate
CAS No.:1336903-85-5
Molecular Formula:C₃₅H₃₆F₃N₃O₂
Molecular Weight:587.685
Hs Code.:

Synonyms:methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Suppliers and Price of methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

There total 6 articles about methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1336903-80-0
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-bromo-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 98-80-6
phenylboronic acid

: 1336903-85-5
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 160 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 1533-03-5
3-(trifluoromethyl)propiophenone

: 1336903-85-5
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 1 h / Reflux

1.2: pH 3

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C / Reflux

4.1: acetonitrile

5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 160 °C / Microwave irradiation

With N-Bromosuccinimide; oxalyl dichloride; sodium carbonate; potassium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In 1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile; 5.1: Suzuki Coupling;

Reference yield:

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 1336903-85-5
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 2.08 h / 100 °C

1.2: Cooling with ice

1.3: pH 1

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C / Reflux

4.1: acetonitrile

5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 160 °C / Microwave irradiation

With N-Bromosuccinimide; oxalyl dichloride; sodium carbonate; potassium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In 1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile; 5.1: Suzuki Coupling;