3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Base Information

Chemical Name:3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid
CAS No.:1336903-88-8
Molecular Formula:C₃₄H₃₄F₃N₃O₂
Molecular Weight:573.658
Hs Code.:

Synonyms:3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

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Chemical Property of 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

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Technology Process of 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

There total 7 articles about 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1336903-85-5
methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 1336903-88-8
3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate; With water; potassium hydroxide; In methanol; at 90 ℃;

With hydrogenchloride; In water; pH=6; Cooling with ice;

Reference yield:

: 1533-03-5
3-(trifluoromethyl)propiophenone

: 1336903-88-8
3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 1 h / Reflux

1.2: pH 3

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C / Reflux

4.1: acetonitrile

5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 160 °C / Microwave irradiation

6.1: potassium hydroxide; water / methanol / 90 °C

6.2: pH 6 / Cooling with ice

With N-Bromosuccinimide; oxalyl dichloride; water; sodium carbonate; potassium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile; 5.1: Suzuki Coupling;

Reference yield:

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 1336903-88-8
3-(1,4'-bipiperidin-1'-ylmethyl)-6-phenyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 2.08 h / 100 °C

1.2: Cooling with ice

1.3: pH 1

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C / Reflux

4.1: acetonitrile

5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.17 h / 160 °C / Microwave irradiation

6.1: potassium hydroxide; water / methanol / 90 °C

6.2: pH 6 / Cooling with ice

With N-Bromosuccinimide; oxalyl dichloride; water; sodium carbonate; potassium hydroxide; dibenzoyl peroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile; 5.1: Suzuki Coupling;