3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxy-N-(4-(methylsulfonamido)phenyl)benzamide

Base Information

Chemical Name:3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxy-N-(4-(methylsulfonamido)phenyl)benzamide
CAS No.:1132935-81-9
Molecular Formula:C₂₃H₂₈N₄O₆S
Molecular Weight:488.565
Hs Code.:

Synonyms:3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxy-N-(4-(methylsulfonamido)phenyl)benzamide

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Chemical Property of 3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxy-N-(4-(methylsulfonamido)phenyl)benzamide

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Technology Process of 3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxy-N-(4-(methylsulfonamido)phenyl)benzamide

There total 8 articles about 3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxy-N-(4-(methylsulfonamido)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1132945-26-6
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride

: 57005-04-6
N-(4-aminophenyl)methanesulfonamide hydrochloride

: 1132935-81-9
3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxy-N-(4-(methylsulfonamido)phenyl)benzamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 15018-03-8
methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate

: 1132935-81-9
3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxy-N-(4-(methylsulfonamido)phenyl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid; acetic acid / 2.5 h / 20 °C

2: potassium carbonate / acetone / Reflux

3: iron; ammonium chloride / methanol; water / 1 h / Reflux

4: toluene / 24 h / Reflux

5: acetic acid / 18.5 h / 120 °C

6: sodium hydroxide / methanol; water; tetrahydrofuran / 12 h / 20 °C

7: thionyl chloride / 1 h / Reflux

8: dichloromethane; pyridine / 18 h / 20 °C

With thionyl chloride; nitric acid; iron; potassium carbonate; ammonium chloride; acetic acid; sodium hydroxide; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; acetic acid; acetone; toluene;
DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

: 372137-83-2
methyl 3-tert-butyl-2-hydroxy-5-nitrobenzoate

: 1132935-81-9
3-(tert-butyl)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxy-N-(4-(methylsulfonamido)phenyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetone / Reflux

2: iron; ammonium chloride / methanol; water / 1 h / Reflux

3: toluene / 24 h / Reflux

4: acetic acid / 18.5 h / 120 °C

5: sodium hydroxide / methanol; water; tetrahydrofuran / 12 h / 20 °C

6: thionyl chloride / 1 h / Reflux

7: dichloromethane; pyridine / 18 h / 20 °C

With thionyl chloride; iron; potassium carbonate; ammonium chloride; sodium hydroxide; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; acetic acid; acetone; toluene;
DOI:10.1021/acs.jmedchem.7b01630