3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride

Base Information

Chemical Name:3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride
CAS No.:1132945-26-6
Molecular Formula:C₁₆H₁₉ClN₂O₄
Molecular Weight:338.791
Hs Code.:

Synonyms:3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride

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Chemical Property of 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride

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Technology Process of 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride

There total 7 articles about 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1132941-16-2
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid

: 1132945-26-6
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride

Guidance literature:: With thionyl chloride; for 2h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 15018-03-8
methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate

: 1132945-26-6
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride

Guidance literature:: Multi-step reaction with 7 steps

1: nitric acid; acetic acid / 2.5 h / 20 °C

2: potassium carbonate / acetone / Reflux

3: iron; ammonium chloride / methanol; water / 1 h / Reflux

4: toluene / 24 h / Reflux

5: acetic acid / 18.5 h / 120 °C

6: sodium hydroxide / methanol; water; tetrahydrofuran / 12 h / 20 °C

7: thionyl chloride / 1 h / Reflux

With thionyl chloride; nitric acid; iron; potassium carbonate; ammonium chloride; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; acetone; toluene;
DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

: 1132941-02-6
methyl 5-amino-3-tert-butyl-2-methoxybenzoate

: 1132945-26-6
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 24 h / Reflux

2: acetic acid / 18.5 h / 120 °C

3: sodium hydroxide / methanol; water; tetrahydrofuran / 12 h / 20 °C

4: thionyl chloride / 1 h / Reflux

With thionyl chloride; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; toluene;
DOI:10.1021/acs.jmedchem.7b01630