Technology Process of C11H14FNO
There total 3 articles about C11H14FNO which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-fluoro-3-methyl-4-(isobutyryl)aminophenyl iodide;
With
para-methylphenylmagnesium bromide;
In
tetrahydrofuran;
at -10 - 0 ℃;
for 0.5h;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at -10 - 0 ℃;
for 0.5h;
carbon dioxide;
In
tetrahydrofuran;
at -10 - 15 ℃;
for 0.333333h;
DOI:10.1021/op200301h
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: para-methylphenylmagnesium bromide / tetrahydrofuran
2.1: sodium perborate; potassium iodide / water; acetic acid / 1.5 h / 5 - 20 °C
2.2: 1 h / 0 - 10 °C
3.1: para-methylphenylmagnesium bromide / tetrahydrofuran / 0.5 h / -10 - 0 °C
3.2: 0.5 h / -10 - 0 °C
3.3: 0.33 h / -10 - 15 °C
With
sodium perborate; para-methylphenylmagnesium bromide; potassium iodide;
In
tetrahydrofuran; water; acetic acid;
DOI:10.1021/op200301h
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium perborate; potassium iodide / water; acetic acid / 1.5 h / 5 - 20 °C
1.2: 1 h / 0 - 10 °C
2.1: para-methylphenylmagnesium bromide / tetrahydrofuran / 0.5 h / -10 - 0 °C
2.2: 0.5 h / -10 - 0 °C
2.3: 0.33 h / -10 - 15 °C
With
sodium perborate; para-methylphenylmagnesium bromide; potassium iodide;
In
tetrahydrofuran; water; acetic acid;
DOI:10.1021/op200301h
