(2E)-3-(1-Acetamido-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)-phenyl]ethyl}acrylamide

Base Information

Chemical Name:(2E)-3-(1-Acetamido-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)-phenyl]ethyl}acrylamide
CAS No.:1299482-89-5
Molecular Formula:C₂₃H₂₀F₆N₂O₂
Molecular Weight:470.414
Hs Code.:

Synonyms:(2E)-3-(1-Acetamido-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)-phenyl]ethyl}acrylamide

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Chemical Property of (2E)-3-(1-Acetamido-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)-phenyl]ethyl}acrylamide

Chemical Property:

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Technology Process of (2E)-3-(1-Acetamido-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)-phenyl]ethyl}acrylamide

There total 6 articles about (2E)-3-(1-Acetamido-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)-phenyl]ethyl}acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1299483-38-7
(2E)-3-(1-Amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

: 108-24-7
acetic anhydride

: 1299482-89-5
(2E)-3-(1-Acetamido-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)-phenyl]ethyl}acrylamide

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; at 20 ℃;

Reference yield:

: 185122-74-1
5-bromo-2,3-dihydro-1H-inden-1-one oxime

: 1299482-89-5
(2E)-3-(1-Acetamido-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)-phenyl]ethyl}acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / water; tetrahydrofuran / 0 °C

2: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / 5 h / 150 °C

3: sodium hydroxide / 1 h / Reflux

4: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 50 °C

5: hydrogenchloride; water / 1,4-dioxane / 20 °C

6: 4-methyl-morpholine / dichloromethane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; water; triethylamine; tris-(o-tolyl)phosphine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 903555-95-3
(±)-tert-butyl (5-bromo-2,3-dihydro-1H-inden-1-yl)carbamate

: 1299482-89-5
(2E)-3-(1-Acetamido-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)-phenyl]ethyl}acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / 5 h / 150 °C

2: sodium hydroxide / 1 h / Reflux

3: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 50 °C

4: hydrogenchloride; water / 1,4-dioxane / 20 °C

5: 4-methyl-morpholine / dichloromethane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; water; triethylamine; tris-(o-tolyl)phosphine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide; palladium diacetate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;