(2E)-3-(1-Amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

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Chemical Name:(2E)-3-(1-Amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide
CAS No.:1299483-38-7
Molecular Formula:C₂₁H₁₈F₆N₂O
Molecular Weight:428.377
Hs Code.:

Synonyms:(2E)-3-(1-Amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

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Chemical Property of (2E)-3-(1-Amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

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Technology Process of (2E)-3-(1-Amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

There total 5 articles about (2E)-3-(1-Amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1299483-37-6
tert-butyl {5-[(1E)-3-oxo-3-({2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}amino)prop-1-en-1-yl]-2,3-dihydro-1H-inden-1-yl}carbamate

: 1299483-38-7
(2E)-3-(1-Amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 185122-74-1
5-bromo-2,3-dihydro-1H-inden-1-one oxime

: 1299483-38-7
(2E)-3-(1-Amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / water; tetrahydrofuran / 0 °C

2: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / 5 h / 150 °C

3: sodium hydroxide / 1 h / Reflux

4: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 50 °C

5: hydrogenchloride; water / 1,4-dioxane / 20 °C

With hydrogenchloride; water; triethylamine; tris-(o-tolyl)phosphine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 903555-95-3
(±)-tert-butyl (5-bromo-2,3-dihydro-1H-inden-1-yl)carbamate

: 1299483-38-7
(2E)-3-(1-Amino-2,3-dihydro-1H-inden-5-yl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / 5 h / 150 °C

2: sodium hydroxide / 1 h / Reflux

3: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / N,N-dimethyl-formamide / 50 °C

4: hydrogenchloride; water / 1,4-dioxane / 20 °C

With hydrogenchloride; water; triethylamine; tris-(o-tolyl)phosphine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide; palladium diacetate; In 1,4-dioxane; N,N-dimethyl-formamide;