Technology Process of C20H26ClNO5
There total 17 articles about C20H26ClNO5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C19H24ClNO5;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran;
at -78 ℃;
for 4h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1021/ol2007296
- Guidance literature:
-
C19H24ClNO5;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
methyl iodide;
at -50 ℃;
for 5h;
Overall yield = 85 %; Overall yield = 21.42 g;
DOI:10.1021/acs.orglett.9b00722
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole; tetrachloromethane; triphenylphosphine / dichloromethane / 15.33 h / 0 - 20 °C / Inert atmosphere
2.1: sodium periodate; sodium hydrogencarbonate / tetrachloromethane; water; acetonitrile / 0.17 h / 20 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: triethylamine / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere
4.1: lithium chloride / tetrahydrofuran / -20 - 0 °C / Inert atmosphere
5.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
5.2: 4 h / -78 °C / Inert atmosphere
With
1H-imidazole; tetrachloromethane; sodium periodate; sodium hexamethyldisilazane; sodium hydrogencarbonate; triethylamine; triphenylphosphine; lithium chloride;
In
tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/ol2007296
